CC BY-NC-ND 4.0 · J Lab Physicians 2023; 15(03): 431-436
DOI: 10.1055/s-0043-1761930
Original Article

A Study of Focal and Segmental Glomerulosclerosis according to the Columbia Classification and Its Correlation with the Clinical Outcome

Swapna Nuguri
1   Department of Pathology, ESIC Medical College, Hyderabad, Telangana, India
Meenakshi Swain
2   Department of Histopathology, Apollo Hospitals, Hyderabad, Telangana, India
Michelle de Padua
2   Department of Histopathology, Apollo Hospitals, Hyderabad, Telangana, India
2   Department of Histopathology, Apollo Hospitals, Hyderabad, Telangana, India
› Author Affiliations
Funding None.


Introduction Focal and segmental glomerulosclerosis (FSGS) is a leading cause of nephrotic syndrome in both adults and children. The “Columbia classification of FSGS” includes five variants; not otherwise specified (NOS), tip, perihilar, cellular, and collapsing variants that may have different prognostic and therapeutic implications.

Materials and Methods This is a retrospective study and was carried out in the Department of Histopathology, Apollo Hospitals, Hyderabad. Of a total of 11,691 kidney biopsies over a 7-year period, from 2006 to 2012, 824 cases were diagnosed as FSGS, of which 610 cases in which detailed clinical findings were available were included in this study. FSGS was then categorized according to the Columbia classification.

Results FSGS, NOS was the predominant histomorphological variant. Serum creatinine was significantly high in the collapsing variant, followed by NOS. Follow-up data was available for 103 cases,72.8% had complete remission, 10.6% had partial remission, and in 16.5 % there was no remission. Relapses were observed in 6.7% cases, two patients (1.9%) succumbed, and 4.8% cases progressed to chronic kidney disease.

Conclusion This study showed that perihilar variant was less prevalent, with tip and cellular variants being more prevalent in Indian subcontinent compared to Western literature. Collapsing variant was also less common.

Authors Contributions

All the authors contributed equally to the manuscript.

Publication History

Received: 01 October 2022

Accepted: 16 December 2022

Article published online:
24 February 2023

© 2023. The Indian Association of Laboratory Physicians. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (

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