Hypoxia and Type-IV Hypersensitivity – Dual Pathogenesis in Adverse Reactions to Hip Implants

Abstract

Background Adverse local tissue reactions (ALTRs) to hip implants affect a high proportion of patients. Described initially in metal-on-metal joints, an increasing number of studies report their occurrence in other types of implants. Due to the huge number of patients with hip implants worldwide, it is urgent to fully understand the mechanisms that cause ALTRs to develop efficient options in terms of follow-up, diagnosis and therapy.

Scope and audience The present review, we analyze the corrosion and wear of the materials used in hip implants, as well as the cell and immunological mechanisms involved, with the aim of providing an updated view of the clinical and scientific contents in the literature for students, orthopedic surgeons and researchers.

Keywords

pseudotumors - synovium - chromium and cobalt - orthopedic implants - hip arthroplasty - implant corrosion

Publikationsverlauf

Eingereicht: 04. Februar 2020

Angenommen: 28. September 2022

Artikel online veröffentlicht:
18. Mai 2023

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