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CC BY-NC-ND 4.0 · Asian J Neurosurg 2023; 18(01): 108-116
DOI: 10.1055/s-0043-1760859
Original Article

Association of ABO Blood Group with Delayed Cerebral Ischemia and Clinical Outcomes Following Aneurysmal Subarachnoid Hemorrhage in Pakistan

Saleha Azeem    *
1   King Edward Medical University, Lahore, Pakistan
3   Department of Neurosurgery, Allama Iqbal Medical College, Jinnah Hospital Lahore, Pakistan
,
Mohammad Ashraf    *
2   Wolfson School of Medicine, University of Glasgow, Scotland, United Kingdom
3   Department of Neurosurgery, Allama Iqbal Medical College, Jinnah Hospital Lahore, Pakistan
,
Usman Ahmad Kamboh
3   Department of Neurosurgery, Allama Iqbal Medical College, Jinnah Hospital Lahore, Pakistan
,
Muhammad Asif Raza
3   Department of Neurosurgery, Allama Iqbal Medical College, Jinnah Hospital Lahore, Pakistan
,
Minaam Farooq 
1   King Edward Medical University, Lahore, Pakistan
3   Department of Neurosurgery, Allama Iqbal Medical College, Jinnah Hospital Lahore, Pakistan
,
Huzaifa Ahmad Cheema 
1   King Edward Medical University, Lahore, Pakistan
3   Department of Neurosurgery, Allama Iqbal Medical College, Jinnah Hospital Lahore, Pakistan
,
Simra Tariq 
3   Department of Neurosurgery, Allama Iqbal Medical College, Jinnah Hospital Lahore, Pakistan
,
Nabeel Choudhary
3   Department of Neurosurgery, Allama Iqbal Medical College, Jinnah Hospital Lahore, Pakistan
,
Syed Shahzad Hussain
3   Department of Neurosurgery, Allama Iqbal Medical College, Jinnah Hospital Lahore, Pakistan
4   Department of Neurosurgery, Gujranwala Medical College, Gujranwala, Pakistan
,
Naveed Ashraf
3   Department of Neurosurgery, Allama Iqbal Medical College, Jinnah Hospital Lahore, Pakistan
› Author Affiliations Funding None.
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Abstract

Background The ABO blood type, due to its various hemostaseologic properties, has been associated with several vascular diseases, including aneurysmal subarachnoid hemorrhage (aSAH). However, the role of ABO blood type in delayed cerebral ischemia (DCI) onset and other clinical outcomes after aSAH is largely unexplored. This study aimed to investigate the association between ABO blood type and outcomes after aSAH, primarily DCI.

Methods A retrospective analysis was made on the data collected from 175 aSAH patients at a tertiary supraregional neurosurgery department over 5 years. Socio-demographic factors, clinical variables (DCI, mFG, WFNS grade, and Glasgow Outcome Scale at discharge), EVD placement, and aneurysm size were analyzed for their association with ABO blood type.

Results DCI was reported in 25% of patients with ‘O’ blood type and 9.6% with ‘non-O’ blood type. A stepwise logistic regression model showed that after adjusting for BMI, mFG, WFNS grade, and EVD placement, ‘O’ type blood group was an independent risk factor for DCI, greatly increasing the risk of DCI as compared to ‘non-O’ type groups (OR = 3.27, 95% CI: 1.21–8.82).

Conclusion This study provides evidence that individuals with ‘O’ blood type may have a higher risk of DCI onset after aSAH. However, further studies are essential to address the limitations of our work and confirm our findings.

Keywords

ABO blood group - subarachnoid hemorrhage - cerebral vasospasm - delayed cerebral ischemia - Pakistan

Note

Data from this work has been previously presented at the following conferences:


35th Annual Meeting of the Pakistan Society of Neurosurgeons held from November 11 to November 13, 2023, at King Edward Medical University, Lahore, Pakistan


62nd Annual Scientific Meeting of the British Society of Haematology held from April 3 to April 5, 2022, at the Manchester Central Convention Complex, Manchester, England, United Kingdom


Ethical Approval

The study was approved by our ethical review board.


* These authors contributed equally and retain the first authorship.




Publication History

Article published online:
15 March 2023

© 2023. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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