CC BY-NC-ND 4.0 · PMIO 2018; 5(01): e14-e23
DOI: 10.1055/s-0043-125339
Original Papers
Eigentümer und Copyright ©Georg Thieme Verlag KG 2018

Antimicrobial Constituents from Leaves of Dolichandrone spathacea and Their Relevance to Traditional Use

Phuc-Dam Nguyen
Institut de Chimie Moléculaire de Reims, CNRS UMR 7312, Reims, France
,
Amin Abedini
Institut de Chimie Moléculaire de Reims, CNRS UMR 7312, Reims, France
Laboratoire de Microbiologie, EA 4691, UFR de Pharmacie, Reims, France
,
Sophie C. Gangloff
Laboratoire de Microbiologie, EA 4691, UFR de Pharmacie, Reims, France
,
Catherine Lavaud
Institut de Chimie Moléculaire de Reims, CNRS UMR 7312, Reims, France
› Author Affiliations
Further Information

Publication History

received 14 July 2017
revised 14 November 2017

accepted 11 December 2017

Publication Date:
12 February 2018 (online)

Abstract

Five new compounds, three iridoid glycosides (1-3) and two triterpenoid saponins (4, 5), along with thirty-two known compounds were isolated from the methanolic extract of the leaves of Dolichandrone spathacea. This traditional medicinal plant is widely used in Asia and India as antiseptic, for bronchitis and thrush treatment, and the methanolic extract has been shown to possess antibacterial activity against methicillin-resistant Staphylococcus aureus. The new iridoids were esterified derivatives of 6-ajugol and 6-catalpol, and the new saponins were glucosides of two polyhydroxy triterpenes with ursan skeleton. Their structures were elucidated by spectroscopic methods, including 1D and 2D NMR experiments and HR-ESI-MS analysis, and from comparison with the literature. This study aimed at investigating extracts and isolated compounds for their antimicrobial activities against bacterial and yeast strains, in order to validate the uses of the plant in folk medicine. The 6-O-esterified iridoids had weaker antibacterial activity; verbascoside and p-methoxycinnamic acid, the major compounds of the methanol extract, possessed strong antibacterial activity, which could account for the traditional antiseptic and anti-infectious uses of the leaves of D. spathacea.

Supporting Information