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Drug Res (Stuttg) 2018; 68(07): 387-394
DOI: 10.1055/s-0043-124968
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Ameliorative Effects of Zataria Multiflora Hydro-Alcoholic extract on Gentamicin Induced Nephrotoxicity in Rats

Saeed Hajihashemi
1   Department of Physiology, Arak University of Medical Sciences, Arak, Iran
,
Tahereh Jafarian
1   Department of Physiology, Arak University of Medical Sciences, Arak, Iran
,
Mahboubeh Ahmadi
1   Department of Physiology, Arak University of Medical Sciences, Arak, Iran
,
Ali Rahbari
2   Department of Pathology, Arak University of Medical Sciences, Arak, Iran
,
Fatemeh Ghanbari
3   Department of Pharmacology, Islamic Azad University, Arak Branch, Arak, Iran
› Author Affiliations
Further Information

Publication History

received 07 November 2017

accepted 13 December 2017

Publication Date:
16 January 2018 (online)

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Abstract

Background Nephrotoxicity is the major side effects of aminoglycoside antibiotics such as gentamicin. The aim of this study was to investigate the therapeutic effects of Z.multiflora (ZM) hydroalcoholic extract on gentamicin-induced nephrotoxicity.

Methods Twenty-eight male Wistar rats categorized into four groups: 1) the control group without injection, 2) the gentamicin treated group (100 mg/kg, i.p) 3) the gentamicin and Z. Multiflora treated group; Z. Multiflora extract(0.8 mg/ml in the drinking water) administered after gentamicin (100 mg/kg, i.p) 4) the normal saline and Z. Multiflora treated group; Z. Multiflora extract (0.8 mg/ml in the drinking water) administered after normal saline injection (2 ml/kg,i.p ).

Results Post-treatment with ZM extract caused a significant reduction in the levels of plasma creatinine and blood urea nitrogen (BUN), absolute and fractional excretion of sodium, malondialdehyed (MDA) level in comparison to gentamicin group. In addition, ZM extract significantly increased creatinine clearance, urine osmolarity, and Renal blood flow (RBF) and the Ferric reducing ability of plasma (FRAP) level which had decreased compared to the control group as a result of treatment with gentamicin.

Conclusion The above result indicated that ZM extract improved renal toxicity of gentamicin via reducing oxidative stress, oxygen-free radicals, and lipid peroxidation.

Key words

gentamicin - nephrotoxicity - zataria multiflora - acute renal failure (ARF) - rat
 

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