Endoscopy 2018; 50(05): 511-517
DOI: 10.1055/s-0043-124765
Innovations and brief communications
© Georg Thieme Verlag KG Stuttgart · New York

Safety of cold snare polypectomy for duodenal adenomas in familial adenomatous polyposis: a prospective exploratory study

Kenta Hamada
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
,
Yoji Takeuchi
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Hideki Ishikawa
Ishikawa Gastroenterological Medical Clinic, Osaka, Japan
,
Yasumasa Ezoe
Ishikawa Gastroenterological Medical Clinic, Osaka, Japan
,
Masamichi Arao
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Sho Suzuki
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Taro Iwatsubo
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Minoru Kato
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Yusuke Tonai
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Satoki Shichijo
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Yasushi Yamasaki
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
,
Noriko Matsuura
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Hiroko Nakahira
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Takashi Kanesaka
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Sachiko Yamamoto
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Tomofumi Akasaka
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Noboru Hanaoka
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Koji Higashino
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Noriya Uedo
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Ryu Ishihara
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Hiroyuki Okada
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
,
Hiroyasu Iishi
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
› Author Affiliations
TRIAL REGISTRATION: Single-center, exploratory, prospective trial UMIN000022525at http://www.umin.ac.jp.
Further Information

Publication History

submitted 18 May 2017

accepted after revision 26 November 2017

Publication Date:
19 January 2018 (eFirst)

Abstract

Background Cold snare polypectomy (CSP) to remove multiple duodenal adenomas (MDAs) in patients with familial adenomatous polyposis (FAP) could be an effective and less invasive method than more extensive surgery. The aim of the present study was to determine the safety of this procedure.

Methods This prospective exploratory study included 10 consecutive patients with FAP and MDAs who underwent CSP for as many as 50 duodenal adenomas. The primary outcome was the incidence of severe adverse events.

Results 10 patients were enrolled and underwent 332 CSPs from June 2016 to January 2017. The median procedure time was 33 minutes (range 25 – 53), and the median number of polyps removed during a single session was 35 (range 10 – 50). Most of the removed polyps were ≤ 10 mm. None of the 10 patients experienced a severe adverse event. One patient developed arterial bleeding during the procedure, but it was easily managed using hemoclips.

Conclusions CSP for MDAs in patients with FAP was safe. The long-term efficacy of this procedure should be investigated.