Exp Clin Endocrinol Diabetes 2018; 126(09): 559-563
DOI: 10.1055/s-0043-124365
Article
© Georg Thieme Verlag KG Stuttgart · New York

Serum CTRP3 Level is Associated with Osteoporosis in Postmenopausal Women[*]

Zhong-Hua Xu
1   Department of Orthopedics, Jintan Affiliated Hospital of Jiangsu University, Jintan, China
,
Xing Zhang
1   Department of Orthopedics, Jintan Affiliated Hospital of Jiangsu University, Jintan, China
,
Hua Xie
1   Department of Orthopedics, Jintan Affiliated Hospital of Jiangsu University, Jintan, China
,
Jin He
1   Department of Orthopedics, Jintan Affiliated Hospital of Jiangsu University, Jintan, China
,
Wen-Chao Zhang
1   Department of Orthopedics, Jintan Affiliated Hospital of Jiangsu University, Jintan, China
,
Dan-Feng Jing
1   Department of Orthopedics, Jintan Affiliated Hospital of Jiangsu University, Jintan, China
,
Xiang Luo
2   Kangda College, Nanjing Medical University, Nanjing, China
› Author Affiliations
Further Information

Publication History

received 08 October 2017
first decision 25 November 2017

accepted 06 December 2017

Publication Date:
08 February 2018 (online)

Abstract

Background As a novel adipokine, CTRP3 involves in various functions of energy metabolism. Recent advance reveals a complex interaction between bone and adipose tissue via the secretion of adipokines.

Aims A hospital-based case-control study was conducted to investigate the role of serum CTRP3 in osteoporosis among postmenopausal women.

Methods Serum levels of CTRP3 and osteocalcin were measured. Bone mineral density (BMD) was obtained on femoral neck and lumbar spines by dual energy X-ray absorptiometry.

Results Serum CTRP3 level was lower in subjects with osteoporosis (76.7±22.1 ng/ml) than it in controls (89.4±22.5 ng/ml) (P<0.001). Meanwhile, the frequency of osteoporosis presented a significant decrease (66.4%, 53.9% and 35.9%, P<0.001), in the tertiles of serum CTRP3. Furthermore, serum CTRP3 witnessed an association with a lower risk of osteoporosis (adjusted odds ratio=0.973, 95% confidence interval [0.963–0.983], P<0.001). Lastly, serum CTRP3 level was positively correlated with femoral BMD (r=0.403, P<0.001), lumbar BMD (r=0.368, P<0.001), and HDL-C (r=0.118, P=0.022), among all participants after adjustment. Meanwhile, CTRP3 presented negative correlations with HOMA-IR (r=−0.136, P=0.008) and insulin (r=−0.192, P <0.001).

Conclusions It shows that a decreased serum level of CTRP3 was independently associated with osteoporosis.

* This hospital-based case-control study showed that a decreased serum level of CTRP3, a novel adipokine involves in various functions of energy metabolism, was independently associated with osteoporosis in postmenopausal women.