CC BY-NC-ND 4.0 · Endosc Int Open 2018; 06(02): E242-E248
DOI: 10.1055/s-0043-124078
Original article
Eigentümer und Copyright ©Georg Thieme Verlag KG 2018

Prospective evaluation of EUS-guided fine needle biopsy in pancreatic mass lesions

M. H. Larsen
1  Odense Pancreas Center (OPAC), Department of Surgery, Odense University Hospital, Odense C, Denmark
,
C. W. Fristrup
1  Odense Pancreas Center (OPAC), Department of Surgery, Odense University Hospital, Odense C, Denmark
,
S. Detlefsen
2  Odense Pancreas Center (OPAC), Department of Pathology, Odense University Hospital, Odense C, Denmark
,
M. B. Mortensen
1  Odense Pancreas Center (OPAC), Department of Surgery, Odense University Hospital, Odense C, Denmark
› Author Affiliations
Further Information

Publication History

submitted 02 July 2017

accepted after revision 20 October 2017

Publication Date:
07 February 2018 (online)

Abstract

Background and study aim Due to the scarcity of specific data on endoscopic ultrasound (EUS)-guided fine-needle biopsies (SharkCore) FNB in the evaluation of pancreatic lesions, we performed a prospective study of the diagnostic performance of EUS SharkCore FNB in patients with pancreatic lesions. The aim of this study was to evaluate the diagnostic accuracy.

Patients and methods Single-center prospective study of 41 consecutive patients referred for EUS-FNB from October 2015 to April 2016 at our center. EUS-FNB was obtained in a predefined setting regarding the procedure and pathological evaluation. Data regarding demographics, lesion, technical parameters, and diagnostic accuracy were obtained.

Results The study included 41 consecutive patients (22 males (54 %); median age 68 years). The average size of the lesions was 28 mm (median: 30 mm). A diagnostic specimen was identified in 40 (98 %) cases during microscopy with an average of 2.4 passes. The route was trans-duodenal in 20 cases (49 %). The histological diagnosis of the specimens was malignant in 29 cases (71 %), benign in 8 (20 %), suspicious in 2 (5 %), atypical in 1 (2 %) and in 1 (2 %) no material for microscopic evaluation was obtained. This led to a diagnostic accuracy of 93 %, sensitivity of 91 % and a specificity of 100 %. 2 cases (5 %) of self-limiting bleeding were observed. The diagnosis at follow up was malignant in 32 (78 %) of the patients.

Conclusions EUS-FNB of pancreatic mass lesions with the SharkCore needle produced specimens with a diagnostic accuracy of 93 %. The procedure was safe and easy to perform, and these data support the use of EUS-FNB in a routine setting.