Exp Clin Endocrinol Diabetes 2018; 126(09): 553-558
DOI: 10.1055/s-0043-124076
Article
© Georg Thieme Verlag KG Stuttgart · New York

Association of Vitamin D Levels and type 2 Diabetes Mellitus in Asian Indians is Independent of Obesity

A. Gupta
1   Department of Endocrinology, Centre for Diabetes Endocrinology & Metabolism
,
M. Aslam
1   Department of Endocrinology, Centre for Diabetes Endocrinology & Metabolism
,
S. Rathi
1   Department of Endocrinology, Centre for Diabetes Endocrinology & Metabolism
,
B. K. Mishra
1   Department of Endocrinology, Centre for Diabetes Endocrinology & Metabolism
,
S. Bhardwaj
1   Department of Endocrinology, Centre for Diabetes Endocrinology & Metabolism
,
R. Jhamb
2   Department of Medicine, University College of Medical Sciences (University of Delhi) and GTB Hospital, Delhi, India
,
S. V. Madhu
1   Department of Endocrinology, Centre for Diabetes Endocrinology & Metabolism
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Publikationsverlauf

received 27. September 2017
first decision 22. November 2017

accepted 01. Dezember 2017

Publikationsdatum:
20. März 2018 (online)

Abstract

Background A large proportion of subjects with type 2 diabetes mellitus (T2DM) in India are non-obese. Asian-Indian subjects with diabetes have been shown to have low vitamin D levels. Whether low vitamin D levels and T2DM in Asian-Indians is attributable to the associated obesity as in caucasians is unclear. Hence we studied the association of vitamin D levels and T2DM in Asian-Indians with or without obesity.

Methods Total of 213 subjects were recruited in four groups, group 1-Non-obese diabetic, group 2-Non-obese non-diabetic, group 3-Obese diabetic and group 4-Obese non-diabetic. Subjects recruited under various groups were matched for age and sex. Anthropometry, skin-fold thickness, fasting and postprandial plasma glucose, HbA1c, fasting insulin, lipids and vitamin D levels were measured in all study subjects and were compared between the groups.

Results Mean age of study population was 41.23±7.43 years. Mean BMI in groups 1,2,3 and 4 was 21.34±1.41, 20.53±2.27, 27.72±2.94 and 27.62±3.37 kg/m2 respectively. Overall 64.3% study subjects had vitamin D deficiency and 27.7% had insufficient vitamin D levels. Significantly lower vitamin D levels were found in diabetic groups 1 and 3 compared to non-diabetic groups 2 and 4. No significant difference was observed in vitamin D levels between groups 1 and 3. Similarly, no significant difference was observed in vitamin D levels between groups 2 and 4. Vitamin D levels did not show any significant correlation with BMI, waist or body fat.

Conclusion Vitamin D levels do not appear to be related to obesity in diabetic as well non-diabetic Asian-Indian individuals.