CC BY-NC-ND 4.0 · PMIO 2018; 5(01): e1-e4
DOI: 10.1055/s-0043-123076
Letters
Eigentümer und Copyright ©Georg Thieme Verlag KG 2018

Evaluation of the Antibacterial, Antioxidant and α-Glucosidase Inhibitory Activities of Withanolides from Physalis gracilis

Gerardo Padierna
1  Instituto de Química, Universidad Nacional Autónoma de México, Cd. Mx., México
,
Ana L. Pérez-Castorena
1  Instituto de Química, Universidad Nacional Autónoma de México, Cd. Mx., México
,
Mahinda Martínez
2  Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Querétaro, México
,
Antonio Nieto-Camacho
1  Instituto de Química, Universidad Nacional Autónoma de México, Cd. Mx., México
,
Jesús Morales-Jiménez
3  División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica-Centro de Investigación, Innovación y Desarrollo de las Zonas Áridas, San Luis Potosí, México
,
Emma Maldonado
1  Instituto de Química, Universidad Nacional Autónoma de México, Cd. Mx., México
› Author Affiliations
Further Information

Publication History

received 15 August 2017
revised 01 November 2017

accepted 13 November 2017

Publication Date:
12 February 2018 (online)

Abstract

A chemical investigation of the leaves, flowers, and stems of Physalis gracilis led to the isolation of three withanolides identified as withanolide D (1), 24,25-dihydrowithanolide D (2), and withaphysacarpin (3). The structures of these compounds were determined by analyses of their spectroscopic data, including 1D and 2D NMR. The antibacterial, antioxidant, and α-glucosidase inhibitory activities of compounds 1 and 3 and derivatives 4 and 5 were evaluated. None of the compounds showed antioxidant or glucosidase inhibitory activity. Also, they were inactive against gram-negative bacteria. However, compound 3 was found active against Bacillus subtilis (MIC=65.5 µM) and compound 5 against Staphylococcus aureus (MIC=27.9 µM).

Supporting Information