Exp Clin Endocrinol Diabetes 2018; 126(10): 604-611
DOI: 10.1055/s-0043-121263
Article
© Georg Thieme Verlag KG Stuttgart · New York

Plasma Free Fatty Acids Metabolic Profile Among Uyghurs and Kazaks With or Without Type 2 Diabetes Based on GC-MS

Xiao-li Ma
1   Central Laboratory of Xinjiang Medical University, Urumqi, China
,
Lei Meng
1   Central Laboratory of Xinjiang Medical University, Urumqi, China
,
Lin-lin Li
2   Basic Medical College, Xinjiang Medical University, Urumqi, China
,
Li-na Ma
2   Basic Medical College, Xinjiang Medical University, Urumqi, China
,
Xin-min Mao
3   College of Traditional Chinese Medicine, Xinjiang Medical University, Xinyi Street 393, Urumuqi, China
› Author Affiliations
Further Information

Publication History

received 14 July 2017
revised06 October 2017

accepted 11 October 2017

Publication Date:
08 November 2017 (online)

Abstract

Free fatty acids (FFAs) participate in a variety of physiological functions. FFAs are associated with the development of type 2 diabetes mellitus (T2DM). Uyghurs and Kazaks have a different prevalence of T2DM, which cannot be explained by traditional risk factors. This study aimed to examine FFAs as potential biomarkers to distinguish between healthy and T2DM Uyghurs and Kazaks. This was a prospective study conducted at the Xianjiang Medical University from 01/2007 to 06/2010 in Uyghurs and Kazaks. The subjects were grouped as T2DM patients (Uyghurs: n=39; Kazaks, n=21) and controls (Uyghurs: n=35; Kazaks, n=40). Gas chromatography-mass spectrometry (GC-MS) and partial least squares discriminant analysis (PLS-DA) models were used to study the FFA profiles between Uyghurs and Kazaks with T2DM. PLS-DA analysis showed that among Kazaks, T2DM patients had lower C22:6, C18:3 n-6, and C20:3 n-6, but higher C22:0 levels compared with controls. Among Uyghurs, the most important variables to discriminate T2DM patients from controls were higher C22:6 and C20:4 n-6, and lower C22:0, C14:1, C18:3 n6, and C20:3 n6. Kazaks and Uyghurs displayed different FFA profiles between patients with T2DM and controls. These results suggest different risk factors and pathogenesis of T2DM between Kazaks and Uyghurs.