Int J Sports Med 2018; 39(02): 133-140
DOI: 10.1055/s-0043-121147
Immunology
© Georg Thieme Verlag KG Stuttgart · New York

Exercise Performed Concomitantly with Particulate Matter Exposure Inhibits Lung Injury

Adriano Silva-Renno
1  Nove de Julho University (UNINOVE), Laboratory of Pulmonary and Exercise Immunology (LABPEI) and Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), Sao Paulo, Brazil
,
Guilherme Crisitanini Baldivia
1  Nove de Julho University (UNINOVE), Laboratory of Pulmonary and Exercise Immunology (LABPEI) and Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), Sao Paulo, Brazil
,
Manoel C. Oliveira-Junior
2  Nove de Julho University - UNINOVE, MSc and PhD Program in Rehabilitation Sciences and MSc in Medicine, São Paulo, Brazil
,
Maysa Alves Rodrigues Brandao-Rangel
1  Nove de Julho University (UNINOVE), Laboratory of Pulmonary and Exercise Immunology (LABPEI) and Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), Sao Paulo, Brazil
,
Elias El-Mafarjeh
1  Nove de Julho University (UNINOVE), Laboratory of Pulmonary and Exercise Immunology (LABPEI) and Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), Sao Paulo, Brazil
,
Marisa Dolhnikoff
3  School of Medicine, Sao Paulo University, Pathology, Sao Paulo, Brazil
,
Thaís Mauad
3  School of Medicine, Sao Paulo University, Pathology, Sao Paulo, Brazil
,
Jôse Mára Britto
4  Pathology (LIM 5), Universidade de Sao Paulo Faculdade de Medicina, Sao Paulo, Brazil
,
Paulo Hilário Nascimento Saldiva
5  Pathology, University of Sao Paulo, São Paulo, Brazil
,
Luis Vicente Franco Oliveira
1  Nove de Julho University (UNINOVE), Laboratory of Pulmonary and Exercise Immunology (LABPEI) and Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), Sao Paulo, Brazil
,
Ana P. Ligeiro-Oliveira
2  Nove de Julho University - UNINOVE, MSc and PhD Program in Rehabilitation Sciences and MSc in Medicine, São Paulo, Brazil
,
Gustavo Silveira Graudenz
1  Nove de Julho University (UNINOVE), Laboratory of Pulmonary and Exercise Immunology (LABPEI) and Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), Sao Paulo, Brazil
,
Rodolfo Paula Vieira
6  Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), School of Medical Sciences of São José dos Campos Humanitas and Universidade Brasil, Laboratory of Pulmonary and Exercise Immunology (LABPEI), São José dos Campos, Brazil
› Author Affiliations
Further Information

Publication History



accepted 19 September 2017

Publication Date:
21 November 2017 (eFirst)

Abstract

Air pollution is a growing problem worldwide, inducing and exacerbating several diseases. Among the several components of air pollutants, particulate matter (PM), especially thick (10–2.5 µm; PM 10) and thin (≤2.5 µm; PM 2.5), are breathable particles that easily can be deposited within the lungs, resulting in pulmonary and systemic inflammation. Although physical activity is strongly recommended, its effects when practiced in polluted environments are questionable. Therefore, the present study evaluated the pulmonary and systemic response of concomitant treadmill training with PM 2.5 and PM 10 exposure. Treadmill training inhibited PM 2.5- and PM 10-induced accumulation of total leukocytes (p<0.001), neutrophils (p<0.001), macrophages (p<0.001) and lymphocytes (p<0.001) in bronchoalveolar lavage (BAL), as well as the BAL levels of IL-1beta (p<0.001), CXCL1/KC (p<0.001) and TNF-alpha (p<0.001), whereas it increased IL-10 levels (p<0.05). Similar effects were observed on accumulation of polymorphonuclear (p<0.01) and mononuclear (p<0.01) cells in the lung parenchyma and in the peribronchial space. Treadmill training also inhibited PM 2.5- and PM 10-induced systemic inflammation, as observed in the number of total leukocytes (p<0.001) and in the plasma levels of IL-1beta (p<0.001), CXCL1/KC (p<0.001) and TNF-alpha (p<0.001), whereas it increased IL-10 levels (p<0.001). Treadmill training inhibits lung and systemic inflammation induced by particulate matter.