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CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2017; 77(11): 1189-1199
DOI: 10.1055/s-0043-120920
GebFra Science
Original Article/Originalarbeit
Georg Thieme Verlag KG Stuttgart · New York

Pregnancy Outcomes in Maternal Neuropsychiatric Illness and Substance Abuse

Article in several languages: English | deutsch
Severine Bartel
1   Fehlbildungsmonitoring Sachsen-Anhalt, Medizinische Fakultät der Otto-von-Guericke Universität Magdeburg, Magdeburg, Germany
,
Serban Dan Costa
2   Universitätsfrauenklinik Magdeburg, Medizinische Fakultät der Otto-von-Guericke Universität Magdeburg, Magdeburg, Germany
,
Siegfried Kropf
3   Institut für Biometrie und Medizinische Informatik (IBMI), Medizinische Fakultät der Otto-von-Guericke Universität Magdeburg, Magdeburg, Germany
,
Anke Redlich
2   Universitätsfrauenklinik Magdeburg, Medizinische Fakultät der Otto-von-Guericke Universität Magdeburg, Magdeburg, Germany
,
Anke Rissmann
1   Fehlbildungsmonitoring Sachsen-Anhalt, Medizinische Fakultät der Otto-von-Guericke Universität Magdeburg, Magdeburg, Germany
› Author Affiliations
Further Information

Publication History

received 07 September 2017
revised 27 September 2017

accepted 09 October 2017

Publication Date:
27 November 2017 (online)

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Abstract

Introduction Worldwide the prevalence of neuropsychiatric illness among women of reproductive age is higher than ever before. This study investigates the influences of maternal substance abuse/dependence and neuropsychiatric illness on pregnancy and neonatal outcomes.

Patients and Methods Using a retrospective study design 185 pregnancies in women with neuropsychiatric illnesses or substance abuse were identified at a single centre over a period of 3.25 years and compared to 4907 pregnancies in healthy women without mental illness. Differences in pre-, peri- and postnatal pregnancy parameters were studied.

Results Numbers of previous abortions on obstetric history were significantly higher in cases compared to controls, women with depression being especially affected. The number of antenatal visits was also higher among cases, especially in women with depression. The caesarean section rate was significantly higher in cases compared to controls. Children of women with neuropsychiatric illness were born at lower gestational ages than those of healthy control mothers, however there were no significant differences between case and control groups for birth weight, head circumference or Apgar scores. Some isolated differences were found for disease-specific case subgroups compared to controls.

Conclusion The study shows a relationship between maternal neuropsychiatric illness and pregnancy outcomes independent of medication use. Rates of spontaneous abortion were higher. Children were born earlier, yet the neonatal outcomes birth weight, head circumference and Apgar score were not worse than children of mentally healthy women.

Key words

pregnancy outcome - neuropsychiatric illness - abortion - fetal outcome - pregnancy
 

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