Drug Res (Stuttg) 2018; 68(05): 245-249
DOI: 10.1055/s-0043-120661
Review
© Georg Thieme Verlag KG Stuttgart · New York

Nano-drug for Pain Medicine

Farshad Hasanzadeh-Kiabi
1   Faculty of Medicine, Department of Anesthesiology, Mazandaran University of Medical Sciences, Sari, Iran
› Author Affiliations
Further Information

Publication History

received 21 July 2017

accepted 02 October 2017

Publication Date:
03 November 2017 (online)

Abstract

Pain is commonly categorized into two diverse groups: acute pain, characterized by early onset and last for a very short time; while chronic pain, characterized by a prolonged pain for least 3 months’ duration. Timely and immediate management of critical pain is critical in reducing its aggravation to chronic pain. There has been successful application of nano-technology, nano-medicine to the treatment and management of pain both in clinical and experimental studies like the fabrication of nano-formulated liposomes to deliver drugs for pain therapy, formulation of non- steroidal anti-inflammatory drugs (NSAIDs). However safety issues related with NSAIDs have impelled the fabrication and the design of new drug formulations that reduces side effects and sustain efficacy. This review will give a concise summary on the available studies on the application of nano-formulated drugs designed for pain treatment and management.

 
  • References

  • 1 Moradkhani MR, Karimi A, Negahdari B. Nanotechnology application to local anaesthesia (LA). Artif cells, nanomedicine, Biotechnol 2017; 1-6
  • 2 Vahabi S, Beiranvand S. Effect of local ropivacaine on hemodynamic responses in craniotomy patients. J Investig Surg 2017; 1-5
  • 3 Carr DB, Goudas LC. Acute pain. Lancet 1999; 353: 2051-2058
  • 4 Bhala N, Emberson J, Merhi A. et al Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: Meta-analyses of individual participant data from randomised trials. Lancet (London, England) 2013; 382: 769-779
  • 5 Schneider V, Lévesque LE, Zhang B. et al. Association of selective and conventional nonsteroidal antiinflammatory drugs with acute renal failure: A population-based, nested case-control analysis. Am J Epidemiol 2006; 164: 881-889
  • 6 McGettigan P, Henry D. Cardiovascular risk with non-steroidal anti-inflammatory drugs: Systematic review of population-based controlled observational studies. PLoS Med. 2011; 8: e1001098
  • 7 Nadri S, Mahmoudvand H, Moradkhani MR. Magnesium sulfate mediate morphine administration reduction in varicocelectomy surgery. J Investig Surg 2017; 1-5
  • 8 Lewis SC, Langman MJS, Laporte J-R. et al. Dose-response relationships between individual nonaspirin nonsteroidal anti-inflammatory drugs (NANSAIDs) and serious upper gastrointestinal bleeding: A meta-analysis based on individual patient data. Br J Clin Pharmacol 2002; 54: 320-326
  • 9 Onoue S, Yamada S, Chan HK. Nanodrugs: Pharmacokinetics and safety. Int J Nanomedicine 2014; 9: 1025-1037
  • 10 Kaminskas LM, McLeod VM, Kelly BD. et al. A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems. Nanomedicine Nanotechnology, Biol Med 2012; 8: 103-111
  • 11 Asthana A, Chauhan AS, Diwan PV. et al. Poly(amidoamine) (PAMAM) dendritic nanostructures for controlled site-specific delivery of acidic anti-inflammatory active ingredient. AAPS PharmSciTech 2005; 6: E536-E542
  • 12 Kaminskas LM, Kelly BD, McLeod VM. et al. Capping methotrexate ??-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated pegylated polylysine dendrimers. Mol Pharm 2011; 8: 338-349
  • 13 Manvelian G, Daniels S, Gibofsky A. The pharmacokinetic parameters of a single dose of a novel nano-formulated, lower-dose oral diclofenac. Postgrad Med 2012; 124: 117-123
  • 14 Onoue S, Takahashi H, Kawabata Y. et al. Formulation design and photochemical studies on nanocrystal solid dispersion of curcumin with improved oral bioavailability. J Pharm Sci 2010; 99: 1871-1881
  • 15 Kato K, Chin K, Yoshikawa T. et al Phase II study of NK105, a paclitaxel-incorporating micellar nanoparticle, for previously treated advanced or recurrent gastric cancer. Invest New Drugs 2012; 30: 1621-1627
  • 16 Onoue S, Kojo Y, Suzuki H. et al. Development of novel solid dispersion of tranilast using amphiphilic block copolymer for improved oral bioavailability. Int J Pharm 2013; 452: 220-226
  • 17 Fanciullino R, Ciccolini J, Milano G. Challenges, expectations and limits for nanoparticles-based therapeutics in cancer: A focus on nano-albumin-bound drugs. Crit Rev Oncol Hematol 2013; 88: 504-513
  • 18 Morgen M, Bloom C, Beyerinck R. et al. Polymeric nanoparticles for increased oral bioavailability and rapid absorption using celecoxib as a model of a low-solubility, high-permeability drug. Pharm Res 2012; 29: 427-440
  • 19 Zhang J, He C, Tang C. et al. Ternary polymeric nanoparticles for oral siRNA delivery. Pharm Res 2013; 30: 1228-1239
  • 20 Chaturvedi K, Ganguly K, Nadagouda MN. et al. Polymeric hydrogels for oral insulin delivery. J Control Release 2013; 165: 129-138
  • 21 Hrkach J, Von Hoff D, Mukkaram Ali M. et al Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile. Sci Transl Med 2012; 4: 128ra39
  • 22 Ramos-Cabrer P, Campos F. Liposomes and nanotechnology in drug development: Focus on neurological targets. Int J Nanomedicine 2013; 8: 951-960
  • 23 Tomii Y. Lipid formulation as a drug carrier for drug delivery. Curr Pharm Des 2002; 8: 467-474
  • 24 Zhang L, Gu F, Chan J. et al. Nanoparticles in Medicine: Therapeutic Applications and Developments. Clin Pharmacol Ther 2008; 83: 761-769
  • 25 Fetterly GJ, Straubinger RM. Pharmacokinetics of paclitaxel-containing liposomes in rats. AAPS PharmSci 2003; 5: E32
  • 26 Pathak P, Nagarsenker M. Formulation and evaluation of lidocaine lipid nanosystems for dermal delivery. AAPS PharmSciTech 2009; 10: 985-992
  • 27 Piao H, Kamiya N, Hirata A. et al. A novel solid-in-oil nanosuspension for transdermal delivery of diclofenac sodium. Pharm Res 2008; 25: 896-901
  • 28 Caraglia M, Luongo L, Salzano G. et al Stealth liposomes encapsulating zoledronic acid: A new opportunity to treat neuropathic pain. Mol Pharm 2013; 10: 1111-1118
  • 29 Fakhravar Z, Ebrahimnejad P, Daraee H. et al. Nanoliposomes: Synthesis methods and applications in cosmetics. J Cosmet Laser Ther 2016; 18: 174-181
  • 30 Nadri S, Mahmoudvand H, Eatemadi A. Magnetic Nanogel Polymer of Bupivacaine for Ankle Block in Rats. J Microencapsul 2016; 33: 656-662
  • 31 Hersh EV, Levin LM, Adamson D. et al. Dose-ranging analgesic study of prosorb?? diclofenac potassium in postsurgical dental pain. Clin Ther 2004; 26: 1215-1227
  • 32 Moore N. Diclofenac potassium 12.5 mg tablets for mild to moderate pain and fever: A review of its pharmacology, clinical efficacy and safety. Clin Drug Investig 2007; 27: 163-195
  • 33 Breivik EK, Barkvoll P, Skovlund E. Combining diclofenac with acetaminophen or acetaminophen-codeine after oral surgery: A randomized, double-blind single-dose study. Clin Pharmacol Ther 1999; 66: 625-635
  • 34 Daniels SE, Baum DR, Clark F. et al. Diclofenac potassium liquid-filled soft gelatin capsules for the treatment of postbunionectomy pain. Curr Med Res Opin 2010; 26: 2375-2384
  • 35 Kowalski M, Stoker DG, Bon C. et al. A pharmacokinetic analysis of diclofenac potassium soft-gelatin capsule in patients after bunionectomy. Am J Ther 2010; 17: 460-468
  • 36 Głuszko P, Bielińska A. Non-steroidal anti-inflammatory drugs and the risk of cardiovascular diseases: Are we going to see the revival of cyclooxygenase-2 selective inhibitors?. Pol Arch Med Wewnętrznej 2009; 119: 231-235
  • 37 Dajani EZ, Islam K. Cardiovascular and gastrointestinal toxicity of selective cyclo-oxygenase-2 inhibitors in man. In: J Physiol Pharmacol 2008; 59: 117-133
  • 38 Moradkhani MR, Karimi A, Negahdari B. Nanotechnology application for pain therapy. Artif Cells, Nanomedicine, Biotechnol 2017; 1-6
  • 39 Moradkhani MR, Karimi A, Negahdari B. et al. Drug anesthesia for children undergoing magnetic resonance imaging: A review. Biomed Pharmacother 2017; 88: 1183-1187
  • 40 Manvelian G, Daniels S, Gibofsky A. A phase 2 study evaluating the efficacy and safety of a novel, proprietary, nano-formulated, lower dose oral diclofenac. Pain Med 2012; 13: 1491-1498
  • 41 Gibofsky A, Silberstein S, Argoff C. et al. Lower-dose diclofenac submicron particle capsules provide early and sustained acute patient pain relief in a phase 3 study. Postgrad Med 2013; 125: 130-138
  • 42 Beiranvand S, Karimi A. Effect of Encapsulated Artemisia aucheri. L Magnetic Nanogel Extract on Shoulder Block in Rat. Drug Res 2017 (Stuttg)
  • 43 Beiranvand S, Eatemadi A, Karimi A. New updates pertaining to drug delivery of local anesthetics in particular bupivacaine using lipid nanoparticles. Nanoscale Res Lett 2016; 11: 1-10
  • 44 Gambling D, Hughes T, Martin G. et al. A comparison of depodurtm, a novel, single-dose extended-release epidural morphine, with standard epidural morphine for pain relief after lower abdominal surgery. Anesth Analg 2005; 100: 1065-1074
  • 45 Nadri S, Mahmoudvand H, Vahabi S. Effect of magnesium sulfate on morphine activity retention to control pain after herniorrhaphy. Pain 2017; 7: 119-125
  • 46 Hinz B, Chevts J, Renner B. et al. Bioavailability of diclofenac potassium at low doses. Br J Clin Pharmacol 2005; 59: 80-84
  • 47 Vahabi S, Rafieian Y, Abbas Zadeh A. The effects of intraoperative esmolol infusion on the postoperative pain and hemodynamic stability after rhinoplasty. J Investig Surg 2017; 1-7
  • 48 Vahabi S, Eatemadi A. Phyto-anesthetics: A mini-review on herb–anesthesia drug interactions. Biomed. Pharmacother. 2016; 84: 1885-1890
  • 49 Zarei F, Negahdari B. Recent progresses in plastic surgery using adipose-derived stem cells, biomaterials and growth factors. J Microencapsul 2017; 1-25
  • 50 Eatemadi A, Daraee H, Zarghami N. et al. Nanofiber: Synthesis and biomedical applications. Artif cells, nanomedicine, Biotechnol 2014; 1-11
  • 51 Tseng Y-Y, Liao J-Y, Chen W-A. et al. Biodegradable poly([{D},{L}]-lactide-co-glycolide) nanofibers for the sustainable delivery of lidocaine into the epidural space after laminectomy. Nanomedicine (Lond) 2014; 9: 77-87
  • 52 Li H, Qiao H, Lu H. et al. Evaluation of the peripheral analgesic effect of sufentanil lipid nanoparticles. J Anesth 2014; 28: 702-707
  • 53 Hassanzadeh-kiabi F, Negahdari B. Antinociceptive synergistic interaction between Achillea millefolium and Origanum vulgare L. extract encapsulated in liposome in rat. Artif Cells, Nanomedicine, Biotechnol 2017; 1-7
  • 54 Altman R, Daniels S, Young CL. Indomethacin submicron particle capsules provide effective pain relief in patients with acute pain: A phase 3 study. Phys Sportsmed 2013; 41: 7-15
  • 55 Chang HI, Yeh MK. Clinical development of liposome-based drugs: Formulation, characterization, and therapeutic efficacy. Int J Nanomedicine 2012; 7: 49-60