Klin Padiatr 2018; 230(01): 5-12
DOI: 10.1055/s-0043-120525
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Interdisziplinäre Konzepte von Pädiatrie und Klinischer Pharmazie zur Optimierung der Antikonvulsivatherapie

Interdisciplinary Concepts of Paediatrics and Clinical Pharmacy to Optimise Anticonvulsant Treatment
Thilo Bertsche
1   Zentrum für Arzneimittelsicherheit und Klinische Pharmazie, Universität Leipzig
,
Martina Patrizia Neininger
1   Zentrum für Arzneimittelsicherheit und Klinische Pharmazie, Universität Leipzig
,
Almuth Kaune
1   Zentrum für Arzneimittelsicherheit und Klinische Pharmazie, Universität Leipzig
,
Pia M. Schumacher
1   Zentrum für Arzneimittelsicherheit und Klinische Pharmazie, Universität Leipzig
,
Henriette K. Dumeier
1   Zentrum für Arzneimittelsicherheit und Klinische Pharmazie, Universität Leipzig
,
Matthias K. Bernhard
2   Klinik und Poliklinik für Kinder und Jugendliche, Zentrum für pädiatrische Forschung, Universitätsklinikum Leipzig
,
Steffen Syrbe
2   Klinik und Poliklinik für Kinder und Jugendliche, Zentrum für pädiatrische Forschung, Universitätsklinikum Leipzig
3   Klinik für Allgemeinpädiatrie, Sektion für Neuropädiatrie und Stoffwechselmedizin, Zentrum für Kinder- und Jugendmedizin, Universitätsklinikum Heidelberg
,
Wieland Kiess
2   Klinik und Poliklinik für Kinder und Jugendliche, Zentrum für pädiatrische Forschung, Universitätsklinikum Leipzig
,
Andreas Merkenschlager
2   Klinik und Poliklinik für Kinder und Jugendliche, Zentrum für pädiatrische Forschung, Universitätsklinikum Leipzig
,
Astrid Bertsche
2   Klinik und Poliklinik für Kinder und Jugendliche, Zentrum für pädiatrische Forschung, Universitätsklinikum Leipzig
› Author Affiliations
Further Information

Publication History

Publication Date:
19 December 2017 (online)

Zusammenfassung

Für die Diagnostik von Epilepsien im Kindes- und Jugendalter und deren Behandlung mit Antikonvulsiva ist Expertise in unterschiedlichen Bereichen nötig. Der Patient profitiert dabei vom Zusammenwirken verschiedener Berufsgruppen. Risiken müssen reduziert und die in klinischen Studien gezeigte Wirksamkeit auch in eine möglichst gute Effektivität unter Routinebedingungen umgesetzt werden. Dabei sollten zunächst Aspekte der Arzneimittelverschreibung durch den Arzt berücksichtigt werden, wie etwa die Auswahl, Kombination und Dosierung der Antikonvulsiva. Dabei sollte die Arzneimittelanwendung nicht vergessen werden. Erst, wenn ein Antikonvulsivum richtig angewendet wird, kann der vom verordnenden Arzt gewünschte Therapieerfolg auch erreicht werden. Dabei sollten sich Maßnahmen nicht nur auf den Pflegedienst, sondern auch auf die Eltern, die Kinder und Jugendlichen selbst sowie Betreuer in Schulen und Kindertageseinrichtungen erstrecken. Durch theoretische Schulungen, praktische Übungen und regelmäßige Einbindung von Apothekern ins interdisziplinäre Behandlungsteam wird vermeidbaren arzneimittelbezogenen Problemen, die zu mangelnder Effektivität und dem Auftreten erhöhter Risiken führen können, vorgebeugt. Auf diese Weise wird nicht nur die Arzneimittel(therapie)sicherheit qualitativ verbessert, sondern auch die Teilhabe und Lebensqualität der Patienten und deren Familien positiv beeinflusst.

Abstract

Summary Expertise in a variety of fields is required for the diagnostic process of epilepsies in children and adolescents as well as for their treatment with anticonvulsants. Patients benefit in the process from the cooperation of different health care professionals. It is of critical importance for risks to be minimised and for the efficacy shown in controlled clinical trials to be maintained in routine conditions. In the first instance, drug prescription procedures, including the choice of anticonvulsants and combinations of drugs and dosing, have to be considered. The administration of drugs has, of course, also to be taken into account. Only if patients are given their anticonvulsants appropriately, the intended success of the therapy can be accomplished. Strategies aimed at improving drug administration have to be directed not only at nurses but also at parents, children and adolescents themselves, as well as caregivers in schools and children's day-care facilities. By providing theoretical teaching, practical training, and routinely including pharmacists in the therapeutic team, drug-related problems that may result in limited effectiveness and increased risks are prevented. As a result, drug (therapy) safety is not only qualitatively improved, but the degree of participation and quality of life of patients and families is improved as well.

 
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