CC BY-NC-ND 4.0 · PMIO 2017; 4(03): e104-e107
DOI: 10.1055/s-0043-120070
Original Papers
Eigentümer und Copyright ©Georg Thieme Verlag KG 2018

Mayombensin, a New Azadirachtin I Derivative with Unusual Structure from Guarea mayombensis

Charlie Djeukeu
1  Faculty of Science, Department of Chemistry, University of Douala, Douala, Cameroon
,
Michel Feussi Tala
2  University of Göttingen, Institute of Organic and Biomolecular Chemistry, Göttingen, Germany
,
Carine Mvot Akak
1  Faculty of Science, Department of Chemistry, University of Douala, Douala, Cameroon
,
Anatole Guy Blaise Azebaze
1  Faculty of Science, Department of Chemistry, University of Douala, Douala, Cameroon
,
Alain Francois Kamdem Wafo
1  Faculty of Science, Department of Chemistry, University of Douala, Douala, Cameroon
,
Jean Duplex Wansi
1  Faculty of Science, Department of Chemistry, University of Douala, Douala, Cameroon
,
Juliette Catherine Vardamides
1  Faculty of Science, Department of Chemistry, University of Douala, Douala, Cameroon
,
Hartmut Laatsch
2  University of Göttingen, Institute of Organic and Biomolecular Chemistry, Göttingen, Germany
› Author Affiliations
Further Information

Publication History

received 18 February 2017
revised 07 June 2017

accepted 08 September 2017

Publication Date:
22 November 2017 (online)

Abstract

A new highly oxidized tetranortriterpenoid, named mayombensin (1), was isolated from the twigs of Guarea mayombensis together with five known compounds and, further, two ceramides, 3,4-dimethyl-secotirucalla-4(28),7,24-trien-3,21-dioic acid (3), the glucosides of stigmasterol and β-sitosterol, and the respective aglyca. The structure of 1 was elucidated by detailed NMR analysis and confirmed as a novel azadirachtin homologue.

Supporting Information