CC BY-NC-ND 4.0 · PMIO 2017; 4(03): e104-e107
DOI: 10.1055/s-0043-120070
Original Papers
Eigentümer und Copyright ©Georg Thieme Verlag KG 2018

Mayombensin, a New Azadirachtin I Derivative with Unusual Structure from Guarea mayombensis

Charlie Djeukeu1, Michel Feussi Tala2, Carine Mvot Akak1, Anatole Guy Blaise Azebaze1, Alain Francois Kamdem Wafo1, Jean Duplex Wansi1, Juliette Catherine Vardamides1, Hartmut Laatsch2
  • 1Faculty of Science, Department of Chemistry, University of Douala, Douala, Cameroon
  • 2University of Göttingen, Institute of Organic and Biomolecular Chemistry, Göttingen, Germany
Further Information

Publication History

received 18 February 2017
revised 07 June 2017

accepted 08 September 2017

Publication Date:
22 November 2017 (online)


A new highly oxidized tetranortriterpenoid, named mayombensin (1), was isolated from the twigs of Guarea mayombensis together with five known compounds and, further, two ceramides, 3,4-dimethyl-secotirucalla-4(28),7,24-trien-3,21-dioic acid (3), the glucosides of stigmasterol and β-sitosterol, and the respective aglyca. The structure of 1 was elucidated by detailed NMR analysis and confirmed as a novel azadirachtin homologue.

Supporting Information