Abstract
Purpose The purpose of this study is to study a heterogeneous group of obese patients undergoing
Bariatric surgery(BS) and its impact on glycemic control. Secondary endpoints include
changes in lipid profile and albuminuria. BS has shown to effectively reduce body-weight.
However, the impact on obesity-related comorbidities varies strongly between individuals.
Especially postoperative short- and long-term improvement of Diabetes is an active
area of investigation.
Methods We conducted a retrospective analysis from baseline to 24 months post bariatric surgery
in our interdisciplinary obesity outpatient-clinic. Follow-up data was collected from
215 patients who had undergone either Roux-en-Y gastric bypass or Sleeve Gastrectomy.
The prevalence of and changes in the major obesity-related comorbidities and concurrent
medication were assessed.
Results Standard parameters of diabetic control showed a U-shaped curve with initial improvement
after six months, but with a gradual worsening after the first year of follow-up.
Weight loss resulted in dose reduction of oral antidiabetic medication and insulin
in 85% and 100% of patients, respectively. With weight loss, a significant improvement
in lipid profile one year after surgery was seen. Subgroup analysis demonstrated gender-
and age-dependent differences in overall benefit.
Conclusions Current data on diabetes remission might be too optimistic and close follow-up should
be provided to prevent gradual worsening of glucose metabolism after BS.
Key words
obesity - bariatric surgery - diabetes mellitus - comorbidities
