Int J Sports Med 2018; 39(01): 21-28
DOI: 10.1055/s-0043-119882
Physiology&Biochemistry
© Georg Thieme Verlag KG Stuttgart · New York

Lifelong Voluntary Exercise Modulates Age-Related Changes in Oxidative Stress

Mohamed Amine Bouzid
Unité de Recherche Education, Motricité, Sport et Santé UR15JS01, Institut Supérieur du Sport et de l'Education Physique de Sfax, Université de Sfax, Tunisie
,
Edith Filaire
Laboratoire CIAMS, EA4532, Université Paris-Sud, Université Orléans, Orléans, France
,
Régis Matran
Service EFR, CHRU de Lille, Boulevard du Pr Leclercq 59037 Lille, France.
,
Sophie Robin
Service EFR, CHRU de Lille, Boulevard du Pr Leclercq 59037 Lille, France.
,
Claudine Fabre
Université de Lille, URePSSS, EA 7369 « Activité Physique Muscle Santé », Faculté des Sciences du Sport et de l’Education Physique, 9 rue de l’Université, 59790 Ronchin, France
› Author Affiliations
Further Information

Publication History



accepted 05 September 2017

Publication Date:
23 November 2017 (eFirst)

Abstract

The hypothesis that aging and regular physical activity could influence oxidative stress has been studied by comparing antioxidant activities (superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GR), ascorbic acid and α-Tocopherol) and malondialdehyde level (MDA) in four groups: young sedentary (n=15; age: 20.3±2.8 years; YS), young active (n=16; age: 21.4±1.9 years; YA), old sedentary (n=15; age: 65.1±3.5 years; OS) and old active (n=17; age: 67.2±4.8 years; OA). Antioxidant activities and MDA level were assessed at rest and after an incremental exercise. There was no difference in resting antioxidant activities and lipid peroxidation between YS and OS. However, resting SOD and GR activities were higher in YA compared to OA (p<0.01 and p<0.05, respectively) and resting MDA level was higher in OA compared to YA (p<0.01). After exercise, a significant increase in SOD and GPX activities was observed in YS, YA and OA (p<0.01). Likewise, after exercise a significant increase of MDA level in YA, OS and OA (p<0.01) was observed. In addition, the comparison of YA to OA and YS to OA revealed similar antioxidant activities and lipid peroxidation between YS and OA, whereas antioxidant activities were higher in YA compared to OA. These data suggest that beneficial effects of regular physical activity in antioxidant defense and lipid peroxidation damage could be impaired by the aging process and that regular physical activity in older adults could maintain age-related decreases in antioxidant defense.