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Horm Metab Res 2017; 49(11): 826-830
DOI: 10.1055/s-0043-119544
Review
© Georg Thieme Verlag KG Stuttgart · New York

The Effects of Selenium Supplementation on Glucose Metabolism and Lipid Profiles Among Patients with Metabolic Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Reza Tabrizi
1   Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
,
Maryam Akbari
1   Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
,
Mahmood Moosazadeh
2   Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran
,
Kamran B. Lankarani
3   Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
,
Seyed Taghi Heydari
3   Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
,
Fariba Kolahdooz
4   Indigenous and Global Health Research, Department of Medicine, University of Alberta, Edmonton, Canada
,
Ali Akbar Mohammadi
5   Petroleum Industry Health Organization, Tehran, Iran
,
Azade Shabani
6   Department of Gynecology and Obstetrics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
Bita Badehnoosh
7   Department of Gynecology and Obstetrics, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
,
Mehri Jamilian
8   Endocrinology and Metabolism Research Center, Arak University of Medical Sciences, Arak, Iran
,
Amin Assarian
9   Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
,
Zatollah Asemi
10   Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
› Author Affiliations
Further Information

Publication History

received 01 August 2017

accepted 05 September 2017

Publication Date:
09 October 2017 (online)

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Abstract

This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of selenium administration on glucose metabolism and lipid profiles among patients with diseases related to metabolic syndrome (MetS). We searched the following databases up to May 2017: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The relevant data were extracted and assessed for quality of the studies according to the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as standardized mean difference (MDs) with 95% confidence intervals (95% CI). Five studies were included in the meta-analyses. The results showed that selenium supplementation significantly reduced insulin levels (SMD −0.42; 95% CI, −0.83 to −0.01) and increased quantitative insulin sensitivity check index (QUICKI) (SMD 0.83; 95% CI, 0.58 to 1.09). Selenium supplementation had no beneficial effects on other glucose homeostasis parameters, such as fasting plasma glucose (FPG) (SMD −0.29; 95% CI, −0.73 to 0.15), homeostasis model assessment of insulin resistance (HOMA-IR) (SMD −0.80; 95% CI, −1.58 to −0.03), and lipid profiles, such as triglycerides (SMD −0.42; 95% CI, −0.83 to −0.01), VLDL- (SMD −0.42; 95% CI, −0.83 to −0.01), total- (SMD −0.42; 95% CI, −0.83 to −0.01), LDL- (SMD 0.02; 95% CI, −0.20 to 0.24), and HDL-cholesterol (SMD 0.16; 95% CI, −0.06 to −0.38). Overall, this meta-analysis showed that selenium administration may lead to an improvement in insulin and QUICKI, but did not affect FPG, HOMA-IR, and lipid profiles.

Key words

selenium - glucose homeostasis - lipid profiles - meta-analysis

Supplementary Material

 

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