Ultrasound Int Open 2017; 03(04): E163-E164
DOI: 10.1055/s-0043-118527
Case Report
© Georg Thieme Verlag KG Stuttgart · New York

Presentation of Gallbladder Chloroma in B-Mode Imaging and Contrast-Enhanced Ultrasound (CEUS) in a Patient with Acute Myelomonocytic Leukemia (AML M5)

Corinna Trenker1, Marius Dohse2, StephanK. Metzelder1, Anette Ramaswamy3, Walter Hundt3, Christian Görg4
  • 1University hospital Gießen and Marburg, Department of Haematology, Oncology and Immunology, Philipps University Marburg, Marburg, Germany
  • 2Universitäsklinikum Gießen und Marburg, Standort Marburg, Department of Pathology, Philipps-University Marburg, Marburg, Germany
  • 3Universitatsklinikum Giessen und Marburg – Standort Marburg, Dianostische Und Interventionelle Radiologie, Marburg, Germany
  • 4University hospital Gießen and Marburg, Interdiciplinary ultrasound center
Further Information

Publication History

received 21 April 2017
revised 24 July 2017

accepted 12 August 2017

Publication Date:
07 December 2017 (online)

Introduction

Chloromas (myeloid sarcoma) are solid tumors consisting of primitive myeloid precursors and have been described in acute myeloid leukemia (AML) and myeloproliferative disorders (Aznab, Mozaffar; Kamalian, Naser; Beiki, Omid et al., Int J Hematol Oncol Stem Cell Res 2015; 9 (1), S. 50–54). In AML, they are observed in 3-8% of all cases, while the frequency varies (J. C.; Edenfield, W. J.; Shields, D. J. et al., Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review. In: J Clin Oncol 1995, 13 (7), S. 1800–1816). Chloromas can be observed at diagnosis, precede the diagnosis, occur during the course of the disease or manifest as a relapse of the AML (Aznab, Mozaffar; Kamalian, Naser; Beiki, Omid et al., Int J Hematol Oncol Stem Cell Res 2015; 9 (1), S. 50–54). They can affect every organ system, with infiltration of bone, skin, soft tissues and lymph nodes being observed most frequently (Aznab, Mozaffar; Kamalian, Naser; Beiki, Omid et al., Int J Hematol Oncol Stem Cell Res 2015; 9 (1), S. 50–54), J. C.; Edenfield, W. J.; Shields, D. J. et al., Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review. In: J Clin Oncol 1995, 13 (7), S. 1800–1816). Single case reports describe chloromas of the gallbladder and the bile ducts (Azin, Arash; Racz, Jennifer M.; Carolina Jimenez, M. et al. Int J Surg Case Rep 2014;5 (6), S. 302–305). In summary, we present the first description of contrast-enhanced ultrasound (CEUS) patterns of a histologically confirmed gallbladder chloroma.