CC BY-NC-ND 4.0 · Endosc Int Open 2017; 05(09): E918-E923
DOI: 10.1055/s-0043-114660
Original article
Eigentümer und Copyright ©Georg Thieme Verlag KG 2017

Alcoholic liver disease is a strong predictor of colorectal polyps in liver transplant recipients

Ann T. Ma1, Amélie Therrien1, 2, Jeanne-Marie Giard1, 2, Daniel von Renteln1, 2, Mickael Bouin1, 2
  • 1Service de gastroentérologie et d’hépatologie, Hôpital St-Luc, Centre Hospitalier de l’Université de Montréal, Montréal, QC, Canada
  • 2Centre de Recherche, Centre Hospitalier de l’Université de Montréal, Montréal, QC, Canada
Further Information

Publication History

submitted 29 September 2016

accepted after revision 02 May 2017

Publication Date:
13 September 2017 (online)

Abstract

Background and aims Colorectal cancer (CRC) is associated with a significantly reduced survival rate in transplant recipients. The prevalence and risk factors of CRC and of colorectal polyps after orthotopic liver transplant (OLT) remain unclear. The study aim was to determine the prevalence of colorectal polyps in OLT recipients. A secondary objective was to explore possible risk factors of polyps.

Patients and materials This was a retrospective single center study of all OLT recipients transplanted between 2007 and 2009. All patients who underwent a colonoscopy 5 ± 5 years after OLT were included. The outcome was colorectal polyps, as identified on colonoscopy. A logistic regression model was performed to identify potential predictors of polyps.

Results Of 164 OLT recipients, 80 were included in this study. Polyps were diagnosed in 37 % of patients before transplant and in 33 % afterwards. With regard to post-transplant lesions, 22 % were advanced adenomas or cancerous. In the regression analysis, the odds of post-transplant polyps were 11 times higher in patients with alcoholic liver disease (OR 11.3, 95 %CI 3.2 – 39.4; P < 0.001).

Conclusion Patients with end-stage liver disease may be at high risk of colorectal polyps before and after liver transplant, and screening should be continued in both contexts. Those with alcoholic liver disease are particularly at risk for post-OLT polyps and may benefit from more intensive screening.