CC BY-NC-ND 4.0 · Neurology International Open 2018; 02(01): E40-E43
DOI: 10.1055/s-0043-111782
Review
Eigentümer und Copyright ©Georg Thieme Verlag KG 2018

Diet, Microbiome and Multiple Sclerosis

Aiden Haghikia
1   Neurologische Klinik der Ruhr-Universität Bochum, St. Josef-Hospital
,
Ralf Linker
2   Neurologische Klinik der Friedrich-Alexander-Universität Erlangen
› Author Affiliations
Further Information

Publication History

Publication Date:
31 January 2018 (online)

Abstract

During recent years, research into the causes of multiple sclerosis (MS), especially in the field of genetic risks of this disease, has made immense advances, thanks to new molecular biology techniques and large consortia. However, the functional relevance of disease-associated risk gene variants remains unclear, and representing about one-third of the overall risk compared to environmental risk factors, plays a smaller role. Thus, the further identification and, where appropriate, prevention of environmental risks is currently the focus of research. Here recently, risk factors for MS have been shown which are closely related to Western diet and lifestyle, such as high consumption of salt and cigarette smoking. In addition, the human gut continues to be the focus of research: with its large surface, the gut offers immense opportunities for interaction between intestinal bacteria, food and their metabolic products, as well as the immune system associated with the gut. In the present paper, we summarize the findings of the constantly growing research field dealing with the gut, nutrition and MS, and discuss how these findings, as shown recently for fatty acids, could have translational-therapeutic potential.

 
  • References

  • 1 Galton F. On men of science, their nature and their nurture. Proceedings of the Royal Institution of Great Britain; 1874
  • 2 Haghikia A, Hohlfeld R, Gold R. et al. Therapies for multiple sclerosis: translational achievements and outstanding needs. Trends Mol Med 2013; 19: 309-319
  • 3 Ascherio A, Munger KL, Lunemann JD. The initiation and prevention of multiple sclerosis. Nat Rev Neurol 2012; 8: 602-612
  • 4 Ascherio A, Munger KL. People with MS should consume a low-salt diet - NO. Mult Scler 2016; 22: 1779-1781
  • 5 Jorg S, Grohme DA, Erzler M. et al. Environmental factors in autoimmune diseases and their role in multiple sclerosis. Cell Mol Life Sci 2016; 73: 4611-4622
  • 6 Odoardi F, Sie C, Streyl K. et al. T cells become licensed in the lung to enter the central nervous system. Nature 2012; 488: 675-679
  • 7 Berer K, Mues M, Koutrolos M. et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 2011; 479: 538-541
  • 8 Sonnenburg JL, Backhed F. Diet-microbiota interactions as moderators of human metabolism. Nature 2016; 535: 56-64
  • 9 Tsabouri S, Priftis KN, Chaliasos N. et al. Modulation of gut microbiota downregulates the development of food allergy in infancy. Allergol Immunopathol 2014; 42: 69-77
  • 10 Dominguez-Bello MG, Costello EK, Contreras M. et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A 2010; 107: 11971-11975
  • 11 Turnbaugh PJ, Hamady M, Yatsunenko T. et al. A core gut microbiome in obese and lean twins. Nature 2009; 457: 480-484
  • 12 Gensollen T, Iyer SS, Kasper DL. et al. How colonization by microbiota in early life shapes the immune system. Science 2016; 352: 539-544
  • 13 Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 2009; 9: 313-323
  • 14 Ochoa-Reparaz J, Mielcarz DW, Begum-Haque S. et al. Gut, bugs, and brain: Role of commensal bacteria in the control of central nervous system disease. Ann Neurol 2011; 69: 240-247
  • 15 Wu HJ, Ivanov II, Darce J. et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 2010; 32: 815-827
  • 16 Ochoa-Reparaz J, Mielcarz DW, Ditrio LE. et al. Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitis. J Immunol 2009; 183: 6041-6050
  • 17 Wekerle H. Nature plus nurture: the triggering of multiple sclerosis. Swiss Med Wkly 2015; 145: w14189
  • 18 Miyake S, Kim S, Suda W. et al. Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species velonging to clostridia XIVa and IV cClusters. PLoS One 2015; 10: e0137429
  • 19 Jangi S, Gandhi R, Cox LM et al. Alterations of the human gut microbiome in multiple sclerosis. Nat Commun 2016; 7:12015 doi: 10.1038/ncomms12015
  • 20 Chen J, Chia N, Kalari KR et al. Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. Sc Rep 2016: 28484 doi:10.1038/srep28484
  • 21 Tremlett H, Fadrosh DW, Faruqi AA. et al. Gut microbiota composition and relapse risk in pediatric MS: A pilot study. J Neurol Sci 2016; 363: 153-157
  • 22 Buscarinu MC, Cerasoli B, Annibali V. et al. Altered intestinal permeability in patients with relapsing-remitting multiple sclerosis: A pilot study. Mult Scler 2016; 23: 442-446
  • 23 Knip M, Siljander H. The role of the intestinal microbiota in type 1 diabetes mellitus. Nat Rev Endocrinol 2016; 12: 154-167
  • 24 Cree BA, Spencer CM, Varrin-Doyer M. et al. Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens. Ann Neurol 2016; 80: 443-447
  • 25 Maslowski KM, Mackay CR. Diet, gut microbiota and immune responses. Nat Immunol 2011; 12: 5-9
  • 26 Torkildsen O, Wergeland S, Bakke S. et al. omega-3 fatty acid treatment in multiple sclerosis (OFAMS Study): A randomized, double-blind, placebo-controlled trial. Arch Neurol 2012; 69: 1044-1051
  • 27 Haghikia A, Jorg S, Duscha A. et al. Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine. Immunity 2015; 43: 817-829
  • 28 Brussow H, Parkinson SJ. You are what you eat. Nat Biotechnol 2014; 32: 243-245
  • 29 Turnbaugh PJ, Ridaura VK, Faith JJ. et al. The effect of diet on the human gut microbiome: A metagenomic analysis in humanized gnotobiotic mice. Sci Transl Med 2009; 1: 6ra14
  • 30 Munger KL, Chitnis T, Ascherio A. Body size and risk of MS in two cohorts of US women. Neurology 2009; 73: 1543-1550
  • 31 Hedstrom AK, Lima Bomfim I, Barcellos L. et al. Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosis. Neurology 2014; 82: 865-872
  • 32 Swank RL, Dugan BB. Effect of low saturated fat diet in early and late cases of multiple sclerosis. Lancet 1990; 336: 37-39
  • 33 Erny D, Hrabe de Angelis AL, Jaitin D. et al Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci 2015; 18: 965-977