Rofo 2017; 189(07): 611-623
DOI: 10.1055/s-0043-110011
Review
© Georg Thieme Verlag KG Stuttgart · New York

White Paper: Interventional MRI: Current Status and Potential for Development Considering Economic Perspectives, Part 1: General Application

Article in several languages: English | deutsch
Jörg Barkhausen
1   Department of Radiology and Nuclear Medicine, University Hospital Schleswig Holstein Luebeck Campus, Germany
,
Thomas Kahn
2   Clinic and Policlinic for Diagnostic and Interventional Radiology, Leipzig, Germany
,
Gabriele A. Krombach
3   Department of Radiology, University Hospital Giessen, Justus Liebig University, Giessen, Germany
,
Christiane K. Kuhl
4   Department of Diagnostic and Interventional Radiology, University Hospital RWTH Aachen, Germany
,
Joachim Lotz
5   Institute for Diagnostic and Interventional Radiology, Georg-August-University Goettingen, Germany
,
David Maintz
6   Department of Radiology, University Hospital of Cologne, Cologne, Germany
,
Jens Ricke
7   Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, Germany
,
Stefan O. Schönberg
8   Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
,
Thomas J. Vogl
9   Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Germany
,
Frank K. Wacker
10   Department for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany
,
German Association of Chairmen in Academic Radiology (KLR)
› Author Affiliations
Further Information

Publication History

20 October 2016

12 April 2017

Publication Date:
26 June 2017 (online)

Abstract

Background MRI is attractive for the guiding and monitoring of interventional procedures due to its high intrinsic soft tissue contrast and the possibility to measure physiologic parameters like flow and cardiac function.

Method The current status of interventional MRI for the clinical routine was analyzed.

Results The effort needed for the development of MR-safe monitoring systems and instruments initially resulted in the application of interventional MRI only for procedures that could not be performed by other means. Accordingly, biopsy of lesions in the breast, which are not detectable by other modalities, has been performed under MRI guidance for decades. Currently, biopsies of the prostate under MRI guidance are established in a similar fashion. At many sites blind biopsy has already been replaced by MR-guided biopsy or at least by the fusion of MR images with ultrasound. Cardiovascular interventions are performed at several centers for ablation as a treatment for atrial fibrillation.

Conclusion Interventional MRI has been established in the clinical routine for a variety of indications. Broader application can be expected in the clinical routine in the future owing to the multiple advantages compared to other techniques.

Key points

  • Due to the significant technical effort, MR-guided interventions are only recommended in the long term for regions in which MRI either facilitates or greatly improves the intervention.

  • Breast biopsy of otherwise undetectable target lesions has long been established in the clinical routine. Prostate biopsy is currently being introduced in the clinical routine for similar reasons. Other methods such as MR-guided focused ultrasound for the treatment of uterine fibroids or tumor ablation of metastases represent alternative methods and are offered in many places.

  • Endovascular MR-guided interventions offer advantages for a number of indications and have already been clinically established for the treatment of children with congenital heart defects and for atrial ablation at individual centers. Greater application can be expected in the future.

Citation format

  • Barkhausen J, Kahn T, Krombach GA et al. White Paper: Interventional MRI: Current Status and Potential for Development Considering Economic Perspectives, Part 1: General Application. Fortschr Röntgenstr 2017; 189: 611 – 623

 
  • References

  • 1 Tzifa A, Krombach GA, Kramer N. et al. Magnetic resonance-guided cardiac interventions using magnetic resonance-compatible devices: a preclinical study and first-in-man congenital interventions. Circ Cardiovasc Interv 2010; 3: 585-592
  • 2 de Bucourt M, Streitparth F, Wonneberger U. et al. Obese patients in an open MRI at 1.0 Tesla: image quality, diagnostic impact and feasibility. Eur Radiol 2011; 21: 1004-1015
  • 3 Wonneberger U, Schnackenburg B, Streitparth F. et al. Evaluation of magnetic resonance imaging-compatible needles and interactive sequences for musculoskeletal interventions using an open high-field magnetic resonance imaging scanner. Cardiovasc Intervent Radiol 2010; 33: 346-351
  • 4 Fischbach F, Bunke J, Thormann M. et al. MR-guided freehand biopsy of liver lesions with fast continuous imaging using a 1.0-T open MRI scanner: experience in 50 patients. Cardiovasc Intervent Radiol 2011; 34: 188-192
  • 5 Fischbach F, Lohfink K, Gaffke G. et al. Magnetic resonance-guided freehand radiofrequency ablation of malignant liver lesions: a new simplified and time-efficient approach using an interactive open magnetic resonance scan platform and hepatocyte-specific contrast agent. Invest Radiol 2013; 48: 422-428
  • 6 Fischbach F, Porsch M, Krenzien F. et al. MR imaging guided percutaneous nephrostomy using a 1.0 Tesla open MR scanner. Cardiovasc Intervent Radiol 2011; 34: 857-863
  • 7 Fischbach F, Eggemann H, Bunke J. et al. MR-guided freehand biopsy of breast lesions in a 1.0-T open MR imager with a near-real-time interactive platform: preliminary experience. Radiology 2012; 265: 359-370
  • 8 Ricke J, Thormann M, Ludewig M. et al. MR-guided liver tumor ablation employing open high-field 1.0T MRI for image-guided brachytherapy. Eur Radiol 2010; 20: 1985-1993
  • 9 Streitparth F, de Bucourt M, Hartwig T. et al. Real-time MR-guided lumbosacral periradicular injection therapy using an open 1.0-T MRI system: an outcome study. Invest Radiol 2013; 48: 471-476
  • 10 Vogl TJ, Dommermuth A, Heinle B. et al. Colorectal cancer liver metastases: long-term survival and progression-free survival after thermal ablation using magnetic resonance-guided laser-induced interstitial thermotherapy in 594 patients: analysis of prognostic factors. Invest Radiol 2014; 49: 48-56
  • 11 Salomonowitz E. MR imaging-guided biopsy and therapeutic intervention in a closed-configuration magnet: single-center series of 361 punctures. Am J Roentgenol 2001; 177: 159-163
  • 12 Kuhl CK, Morakkabati N, Leutner CC. et al. MR imaging--guided large-core (14-gauge) needle biopsy of small lesions visible at breast MR imaging alone. Radiology 2001; 220: 31-39
  • 13 Franiel T. Multiparametric magnetic resonance imaging of the prostate – technique and clinical applications. Fortschr Röntgenstr 2011; 183: 607-617
  • 14 Turkbey B, Choyke PL. Multiparametric MRI and prostate cancer diagnosis and risk stratification. Curr Opin Urol 2012; 22: 310-315
  • 15 Fradet V, Kurhanewicz J, Cowan JE. et al. Prostate cancer managed with active surveillance: role of anatomic MR imaging and MR spectroscopic imaging. Radiology 2010; 256: 176-183
  • 16 Siddiqui MM, Rais-Bahrami S, Turkbey B. et al. Comparison of MR/ultrasound fusion-guided biopsy with ultrasound-guided biopsy for the diagnosis of prostate cancer. JAMA 2015; 313: 390-397
  • 17 Hoeks CM, Vos EK, Bomers JG. et al. Diffusion-weighted magnetic resonance imaging in the prostate transition zone: histopathological validation using magnetic resonance-guided biopsy specimens. Invest Radiol 2013; 48: 693-701
  • 18 Hoeks CM, Barentsz JO, Hambrock T. et al. multiparametric MR imaging for detection, localization, and staging. Radiology 2011; 261: 46-66
  • 19 Cornud F, Delongchamps NB, Mozer P. et al. Value of multiparametric MRI in the work-up of prostate cancer. Curr Urol Rep 2012; 13: 82-92
  • 20 Schlemmer HP. Multiparametric MRI of the prostate: method for early detection of prostate cancer?. Fortschr Röntgenstr 2010; 182: 1067-1075
  • 21 Djavan B, Milani S, Remzi M. Prostate biopsy: who, how and when. An update. Can J Urol 2005; 12: 44-48
  • 22 Eichler K, Hempel S, Wilby J. et al. Diagnostic value of systematic biopsy methods in the investigation of prostate cancer: a systematic review. J Urol 2006; 175: 1605-1612
  • 23 Pokorny MR, de RM, Duncan E. et al. Prospective study of diagnostic accuracy comparing prostate cancer detection by transrectal ultrasound-guided biopsy versus magnetic resonance (MR) imaging with subsequent MR-guided biopsy in men without previous prostate biopsies. Eur Urol 2014; 66: 22-29
  • 24 Wagenlehner FM, van OE, Tenke P. et al. Infective complications after prostate biopsy: outcome of the Global Prevalence Study of Infections in Urology (GPIU) 2010 and 2011, a prospective multinational multicentre prostate biopsy study. Eur Urol 2013; 63: 521-527
  • 25 Kuhl CK. Current status of breast MR imaging. Part 2. Clinical applications. Radiology 2007; 244: 672-691
  • 26 Mann RM, Kuhl CK, Kinkel K. et al. Breast MRI: guidelines from the European Society of Breast Imaging. Eur Radiol 2008; 18: 1307-1318
  • 27 American College of Radiology (ACR). ACR practice guideline for the performance of magnetic resonance imaging-guided breast interventional procedures. http://www.acr.org/~/media/ACR/Documents/PGTS/guidelines/MRI_Guided_Breast.pdf (letzter Zugriff 14 April 2016)
  • 28 AWMF, Deutsche Krebsgesellschaft e. V., Deutsche Krebshilfe e.V. Interdisziplinäre S3-Leitlinie für die Diagnostik, Therapie und Nachsorge des Mammakarzinoms. Aktualisierung 2012. http://www.krebsgesellschaft.de/download/S3_Brustkrebs_Update_2012_OL_Langversion.pdf (letzter Zugriff 14 April 2016)
  • 29 Liberman L, Bracero N, Morris E. et al. MRI-guided 9-gauge vacuum-assisted breast biopsy: initial clinical experience. Am J Roentgenol 2005; 185: 183-193
  • 30 Orel SG, Rosen M, Mies C. et al. MR imaging-guided 9-gauge vacuum-assisted core-needle breast biopsy: initial experience. Radiology 2006; 238: 54-61
  • 31 Meeuwis C, Veltman J, van Hall HN. et al. MR-guided breast biopsy at 3T: diagnostic yield of large core needle biopsy compared with vacuum-assisted biopsy. Eur Radiol 2012; 22: 341-349
  • 32 Noroozian M, Gombos EC, Chikarmane S. et al. Factors that impact the duration of MRI-guided core needle biopsy. Am J Roentgenol 2010; 194: W150-W157
  • 33 Perlet C, Heywang-Kobrunner SH, Heinig A. et al. Magnetic resonance-guided, vacuum-assisted breast biopsy: results from a European multicenter study of 538 lesions. Cancer 2006; 106: 982-990
  • 34 Friedman P, Enis S, Pinyard J. Magnetic resonance imaging-guided vacuum-assisted breast biopsy: an initial experience in a community hospital. Can Assoc Radiol J 2009; 60: 196-200
  • 35 Fischer U, Kopka L, Grabbe E. Magnetic resonance guided localization and biopsy of suspicious breast lesions. Top Magn Reson Imaging 1998; 9: 44-59
  • 36 Schrading S, Simon B, Braun M. et al. MRI-guided breast biopsy: influence of choice of vacuum biopsy system on the mode of biopsy of MRI-only suspicious breast lesions. Am J Roentgenol 2010; 194: 1650-1657
  • 37 Rauch GM, Dogan BE, Smith TB. et al. Outcome analysis of 9-gauge MRI-guided vacuum-assisted core needle breast biopsies. Am J Roentgenol 2012; 198: 292-299
  • 38 Shaylor SD, Heller SL, Melsaether AN. et al. Short interval follow-up after a benign concordant MR-guided vacuum assisted breast biopsy – is it worthwhile?. Eur Radiol 2014; 24: 1176-1185
  • 39 Heywang-Kobrunner SH. Contrast-enhanced magnetic resonance imaging of the breast. Invest Radiol 1994; 29: 94-104
  • 40 Orel SG, Schnall MD, Newman RW. et al. MR imaging-guided localization and biopsy of breast lesions: initial experience. Radiology 1994; 193: 97-102
  • 41 Kuhl CK, Elevelt A, Leutner CC. et al. Interventional breast MR imaging: clinical use of a stereotactic localization and biopsy device. Radiology 1997; 204: 667-675
  • 42 Daniel BL, Birdwell RL, Ikeda DM. et al. Breast lesion localization: a freehand, interactive MR imaging-guided technique. Radiology 1998; 207: 455-463
  • 43 Bedrosian I, Schlencker J, Spitz FR. et al. Magnetic resonance imaging-guided biopsy of mammographically and clinically occult breast lesions. Ann Surg Oncol 2002; 9: 457-461
  • 44 Morris EA, Liberman L, Dershaw DD. et al. Preoperative MR imaging-guided needle localization of breast lesions. Am J Roentgenol 2002; 178: 1211-1220
  • 45 Lampe D, Hefler L, Alberich T. et al. The clinical value of preoperative wire localization of breast lesions by magnetic resonance imaging--a multicenter study. Breast Cancer Res Treat 2002; 75: 175-179
  • 46 Friedman P, Sanders L, Russo J. et al. Detection and localization of occult lesions using breast magnetic resonance imaging: initial experience in a community hospital. Acad Radiol 2005; 12: 728-738
  • 47 Landheer ML, Veltman J, van ER. et al. MRI-guided preoperative wire localization of nonpalpable breast lesions. Clin Imaging 2006; 30: 229-233
  • 48 Gossmann A, Bangard C, Warm M. et al. Real-time MR-guided wire localization of breast lesions by using an open 1.0-T imager: initial experience. Radiology 2008; 247: 535-542
  • 49 Krug KB, Ulhaas A, Hellmich M. et al. Impact of clinical and lesion characteristics on the results of MR-guided wire localizations of the breast using an open 1.0-T MRI system. Invest Radiol 2013; 48: 445-451
  • 50 Fink C, Bock M, Umathum R. et al. Renal embolization: feasibility of magnetic resonance-guidance using active catheter tracking and intraarterial magnetic resonance angiography. Invest Radiol 2004; 39: 111-119
  • 51 Seppenwoolde JH, Bartels LW, van der Weide R. et al. Fully MR-guided hepatic artery catheterization for selective drug delivery: a feasibility study in pigs. J Magn Reson Imaging 2006; 23: 123-129
  • 52 Spuentrup E, Ruebben A, Schaeffter T. et al. Magnetic resonance – guided coronary artery stent placement in a swine model. Circulation 2002; 105: 874-879
  • 53 Qiu B, Gao F, Karmarkar P. et al. Intracoronary MR imaging using a 0.014-inch MR imaging-guidewire: toward MRI-guided coronary interventions. J Magn Reson Imaging 2008; 28: 515-518
  • 54 Neizel M, Kramer N, Schutte A. et al. Magnetic resonance imaging of the cardiac venous system and magnetic resonance-guided intubation of the coronary sinus in swine: a feasibility study. Invest Radiol 2010; 45: 502-506
  • 55 Hilbert S, Sommer P, Gutberlet M. et al. Real-time magnetic resonance-guided ablation of typical right atrial flutter using a combination of active catheter tracking and passive catheter visualization in man: initial results from a consecutive patient series. Europace 2016; 18: 572-577
  • 56 Voit D, Zhang S, Unterberg-Buchwald C. et al. Real-time cardiovascular magnetic resonance at 1.5 T using balanced SSFP and 40 ms resolution. J Cardiovasc Magn Reson 2013; 15: 79
  • 57 Joseph A, Kowallick JT, Merboldt KD. et al. Real-time flow MRI of the aorta at a resolution of 40 msec. J Magn Reson Imaging 2014; 40: 206-213
  • 58 Tzifa A, Schaeffter T, Razavi R. MR imaging-guided cardiovascular interventions in young children. Magn Reson Imaging Clin N Am 2012; 20: 117-128
  • 59 Valverde I, Hussain T, Razavi R. Novel imaging techniques for the diagnosis and treatment of congenital heart defects: MR-guided interventions and beyond. Future Cardiol 2012; 8: 149-152
  • 60 Krueger JJ, Ewert P, Yilmaz S. et al. Magnetic resonance imaging-guided balloon angioplasty of coarctation of the aorta: a pilot study. Circulation 2006; 113: 1093-1100
  • 61 Moore P. MRI-guided congenital cardiac catheterization and intervention: the future?. Catheter Cardiovasc Interv 2005; 66: 1-8
  • 62 Razavi R, Hill DL, Keevil SF. et al. Cardiac catheterisation guided by MRI in children and adults with congenital heart disease. Lancet 2003; 362: 1877-1882
  • 63 Abu Hazeem AA, Dori Y, Whitehead KK. et al. X-ray magnetic resonance fusion modality may reduce radiation exposure and contrast dose in diagnostic cardiac catheterization of congenital heart disease. Catheter Cardiovasc Interv 2014; 84: 795-800
  • 64 Downing TE, Dori Y, Harris MA. et al. successful transcatheter device occlusion using magnetic resonance imaging X-ray fusion. Congenit Heart Dis 2014; 9: E199-E203
  • 65 Krombach GA, Pfeffer JG, Kinzel S. et al. MR-guided percutaneous intramyocardial injection with an MR-compatible catheter: feasibility and changes in T1 values after injection of extracellular contrast medium in pigs. Radiology 2005; 235: 487-494
  • 66 Eitel C, Hindricks G, Grothoff M. et al. Catheter ablation guided by real-time MRI. Curr Cardiol Rep 2014; 16: 511
  • 67 Grothoff M, Piorkowski C, Eitel C. et al. MR imaging-guided electrophysiological ablation studies in humans with passive catheter tracking: initial results. Radiology 2014; 271: 695-702
  • 68 Eitel C, Piorkowski C, Hindricks G. et al. Electrophysiology study guided by real-time magnetic resonance imaging. Eur Heart J 2012; 33: 1975
  • 69 Nordbeck P, Hiller KH, Fidler F. et al. Feasibility of contrast-enhanced and nonenhanced MRI for intraprocedural and postprocedural lesion visualization in interventional electrophysiology: animal studies and early delineation of isthmus ablation lesions in patients with typical atrial flutter. Circ Cardiovasc Imaging 2011; 4: 282-294
  • 70 Piorkowski C, Grothoff M, Gaspar T. et al. Cavotricuspid isthmus ablation guided by real-time magnetic resonance imaging. Circ Arrhythm Electrophysiol 2013; 6: e7-e10
  • 71 Sommer P, Grothoff M, Eitel C. et al. Feasibility of real-time magnetic resonance imaging-guided electrophysiology studies in humans. Europace 2013; 15: 101-108
  • 72 Nazarian S, Bluemke DA, Lardo AC. et al. Magnetic resonance assessment of the substrate for inducible ventricular tachycardia in nonischemic cardiomyopathy. Circulation 2005; 112: 2821-2825
  • 73 Stevens SM, Tung R, Rashid S. et al. Device artifact reduction for magnetic resonance imaging of patients with implantable cardioverter-defibrillators and ventricular tachycardia: late gadolinium enhancement correlation with electroanatomic mapping. Heart Rhythm 2014; 11: 289-298
  • 74 Moche M, Trampel R, Kahn T. et al. Navigation concepts for MR image-guided interventions. J Magn Reson Imaging 2008; 27: 276-291
  • 75 Meeuwis C, Mann RM, Mus RD. et al. MRI-guided breast biopsy at 3T using a dedicated large core biopsy set: feasibility and initial results. Eur J Radiol 2011; 79: 257-261
  • 76 Tilak G, Tuncali K, Song SE. et al. 3T MR-guided in-bore transperineal prostate biopsy: A comparison of robotic and manual needle-guidance templates. J Magn Reson Imaging 2015; 42: 63-71
  • 77 Busse H, Garnov N, Thormer G. et al. Flexible add-on solution for MR image-guided interventions in a closed-bore scanner environment. Magn Reson Med 2010; 64: 922-928
  • 78 Martin AJ, Hall WA, Roark C. et al. Minimally invasive precision brain access using prospective stereotaxy and a trajectory guide. J Magn Reson Imaging 2008; 27: 737-743
  • 79 Busse H, Kahn T, Moche M. Navigation concepts for magnetic resonance imaging-guided musculoskeletal interventions. Top Magn Reson Imaging 2011; 22: 179-188
  • 80 Rothgang E, Gilson WD, Wacker F. et al. Rapid freehand MR-guided percutaneous needle interventions: an image-based approach to improve workflow and feasibility. J Magn Reson Imaging 2013; 37: 1202-1212
  • 81 Krombach GA, Spetzger U, Rohde V. et al. Intraoperative localization of functional regions in the sensorimotor cortex by neuronavigation and cortical mapping. Comput Aided Surg 1998; 3: 64-73
  • 82 Torcuator RG, Hulou MM, Chavakula V. et al. Intraoperative real-time MRI-guided stereotactic biopsy followed by laser thermal ablation for progressive brain metastases after radiosurgery. J Clin Neurosci 2016; 24: 68-73
  • 83 Roder C, Charyasz-Leks E, Breitkopf M. et al. Resting-state functional MRI in an intraoperative MRI setting: proof of feasibility and correlation to clinical outcome of patients. J Neurosurg 2016; 1-9
  • 84 Sylvester PT, Evans JA, Zipfel GJ. et al. Combined high-field intraoperative magnetic resonance imaging and endoscopy increase extent of resection and progression-free survival for pituitary adenomas. Pituitary 2015; 18: 72-85