Exp Clin Endocrinol Diabetes 2017; 125(07): 436-440
DOI: 10.1055/s-0043-103967
Article
© Georg Thieme Verlag KG Stuttgart · New York

Effects of Cycling and Exergaming on Neurotrophic Factors in Elderly Type 2 Diabetic Men – A Preliminary Investigation

Christian Brinkmann1, Leonie Schäfer1, Magd Masoud1, Joachim Latsch2, Daniel Lay2, Wilhelm Bloch1, Klara Brixius1
  • 1Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany
  • 2Department of Preventive and Rehabilitative Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany
Further Information

Publication History

received 15 October 2016
revised 11 February 2017

accepted 14 February 2017

Publication Date:
25 April 2017 (eFirst)

Abstract

Patients with type 2 diabetes mellitus (T2DM) are at increased risk of developing neurodegenerative diseases. There is growing evidence that repeated exercise-induced transient increases in neurotrophic factors can augment neurogenesis and neuroplasticity. This pilot study compares the effects of 30-min submaximal cycling with those of exergaming (combining exercise and video gaming) at the same duration and same rating of perceived exertion (BORG RPE: 14-15) on serum neurotrophic factors in 8 elderly non-insulin-dependent T2DM patients (71±4 years) (2×2 crossover design). Brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF)-1 levels were quantified using enzyme-linked immunosorbent assay (ELISA) kits. Heart rates were almost equal during cycling and exergaming, while lactate values were significantly higher during cycling (cycling versus exergaming: 3.7±1.1 versus 2.5±1.2 mmol/l, p<0.05). BDNF and VEGF levels were increased significantly post-cycling (+20%,+14%, p<0.05). No other significant pre-post changes were evident. This study demonstrates that acute exercise can increase neurotrophic factors (BDNF, VEGF) in elderly T2DM patients, depending on exercise mode.