OP-Journal 2017; 33(02): 149-158
DOI: 10.1055/s-0043-102341
Fachwissen
Georg Thieme Verlag KG Stuttgart · New York

Management des infizierten Implantats im Gesichts-/Schädelbereich

Management of Infected Implants in the Craniofacial Region
Julian Weiser
,
Christian Lohse
,
Kilian Kreutzer
,
Anders Hennigsen
,
Max Heiland
,
Alexander Gröbe
Further Information

Publication History

Publication Date:
15 May 2017 (online)

Zusammenfassung

Durch die Möglichkeit der Implantation von Fremdmaterial wurden die medizinischen Therapiemöglichkeiten auch im Gesichtsschädelbereich zum Vorteil des Patienten substanziell erweitert. Neben den offensichtlichen Vorteilen der fehlenden Entnahmemorbidität und unbegrenzten Verfügbarkeit ist auf der anderen Seite als häufigste Komplikation die fremdmaterialassoziierte Infektion zu nennen. Der Gesichtsschädelbereich ist durch seine verbesserte Gewebeperfusion gegenüber anderen anatomischen Arealen privilegiert, daraus ergeben sich Auswirkungen auf den Verlauf und somit auch auf das Management von Infektionen in diesem Bereich. Dieser Artikel soll eine Übersicht über die Therapiemöglichkeiten von fremdmaterialassoziierten Infektionen sowohl dentaler Implantate, Osteosynthesematerial als auch im Rahmen der Kranioplastik liefern.

Abstract

The implantation of alloplastic materials substantially contributed to medical treatment in the craniomaxillofacial region. Besides obvious advantages, such as the lack of donor site morbidity and the infinite availability of the material itself, implants also have disadvantages. Of these disadvantages, infection is the most significant as it is the most common complication associated with the treatment. With regards to tissue perfusion the craniomaxillofacial complex is at an advantage when compared to many other anatomical regions such as the extremities. This fact has implications on both the course and the management of device related infections in this area. The aim of this article is to provide an overview of the treatment options for infections related to dental implants while also reviewing the management of infection following osteosynthesis and cranioplasty.

 
  • Literatur

  • 1 Klinge B, Hultin M, Berglundh T. Peri-implantitis. Dent Clin North Am 2005; 49: 661-676
  • 2 Simonis P, Dufour T, Tenenbaum H. Long-term implant survival and success: a 10–16-year follow-up of non-submerged dental implants. Clin Oral Implants Res 2010; 21: 772-777
  • 3 Khammissa RA, Feller L, Meyerov R. et al. Peri-implant mucositis and peri-implantitis: clinical and histopathological characteristics and treatment. SADJ 2012; 67: 122 124–126
  • 4 Heitz-Mayfield LJ. Peri-implant diseases: diagnosis and risk indicators. J Clin Periodontol 2008; 35 (8 Suppl.): S292-S304
  • 5 Heitz-Mayfield LJ, Huynh-Ba G. History of treated periodontitis and smoking as risks for implant therapy. Int J Oral Maxillofac Implants 2009; 24 (Suppl.) S39-S68
  • 6 Wilson jr. TG. The positive relationship between excess cement and peri-implant disease: a prospective clinical endoscopic study. J Periodontol 2009; 80: 1388-1392
  • 7 Derks J, Tomasi C. Peri-implant health and disease. A systematic review of current epidemiology. J Clin Periodontol 2015; 42 (Suppl. 16) S158-S171
  • 8 Schwarz FB, Becker J. Periimplantäre Infektionen. Ein Update zur Epidemiologie, Ätiologie, Diagnostik, Prävention und Therapie. Implantologie 2015; 23: 247-259
  • 9 Froum SJ, Rosen PS. A proposed classification for peri-implantitis. Int J Periodontics Restorative Dent 2012; 32: 533-540
  • 10 Canullo L, Penarrocha-Oltra D, Covani U. et al. Microbiologic and clinical findings of implants in healthy condition and with peri-implantitis. Int J Oral Maxillofac Implants 2015; 30: 834-842
  • 11 Unursaikhan O, Lee JS, Cha JK. et al. Comparative evaluation of roughness of titanium surfaces treated by different hygiene instruments. J Periodontal Implant Sci 2012; 42: 88-94
  • 12 Karring ES, Stavropoulos A, Ellegaard B. et al. Treatment of peri-implantitis by the Vector system. Clin Oral Implants Res 2005; 16: 288-293
  • 13 Persson GR, Samuelsson E, Lindahl C. et al. Mechanical non-surgical treatment of peri-implantitis: a single-blinded randomized longitudinal clinical study. II. Microbiological results. J Clin Periodontol 2010; 37: 563-573
  • 14 Tastepe CS, Liu Y, Visscher CM. et al. Cleaning and modification of intraorally contaminated titanium discs with calcium phosphate powder abrasive treatment. Clin Oral Implants Res 2013; 24: 1238-1246
  • 15 Tastepe CS, van Waas R, Liu Y. et al. Air powder abrasive treatment as an implant surface cleaning method: a literature review. Int J Oral Maxillofac Implants 2012; 27: 1461-1473
  • 16 Sahm N, Becker J, Santel T. et al. Non-surgical treatment of peri-implantitis using an air-abrasive device or mechanical debridement and local application of chlorhexidine: a prospective, randomized, controlled clinical study. J Clin Periodontol 2011; 38: 872-878
  • 17 Muthukuru M, Zainvi A, Esplugues EO. et al. Non-surgical therapy for the management of peri-implantitis: a systematic review. Clin Oral Implants Res 2012; 23 (Suppl. 06) S77-S83
  • 18 Grenier D, Plamondon P, Sorsa T. et al. Inhibition of proteolytic, serpinolytic, and progelatinase-b activation activities of periodontopathogens by doxycycline and the non-antimicrobial chemically modified tetracycline derivatives. J Periodontol 2002; 73: 79-85
  • 19 Park JB. Effects of doxycycline, minocycline, and tetracycline on cell proliferation, differentiation, and protein expression in osteoprecursor cells. J Craniofac Surg 2011; 22: 1839-1842
  • 20 Renvert S, Lessem J, Dahlen G. et al. Topical minocycline microspheres versus topical chlorhexidine gel as an adjunct to mechanical debridement of incipient peri-implant infections: a randomized clinical trial. J Clin Periodontol 2006; 33: 362-369
  • 21 Renvert S, Lessem J, Dahlen G. et al. Mechanical and repeated antimicrobial therapy using a local drug delivery system in the treatment of peri-implantitis: a randomized clinical trial. J Periodontol 2008; 79: 836-844
  • 22 Machtei EE, Frankenthal S, Levi G. et al. Treatment of peri-implantitis using multiple applications of chlorhexidine chips: a double-blind, randomized multi-centre clinical trial. J Clin Periodontol 2012; 39: 1198-1205
  • 23 Bassetti M, Schar D, Wicki B. et al. Anti-infective therapy of peri-implantitis with adjunctive local drug delivery or photodynamic therapy: 12-month outcomes of a randomized controlled clinical trial. Clin Oral Implants Res 2014; 25: 279-287
  • 24 Ramanauskaite A, Daugela P, Juodzbalys G. Treatment of peri-implantitis: meta-analysis of findings in a systematic literature review and novel protocol proposal. Quintessence Int 2016; 47: 379-393
  • 25 Mombelli A, Moëne R, Decaillet F. Surgical treatments of peri-implantitis. Eur J Oral Implantol 2012; 5 (Suppl.) S61-S70
  • 26 Serino G, Turri A. Outcome of surgical treatment of peri-implantitis: results from a 2-year prospective clinical study in humans. Clin Oral Implants Res 2011; 22: 1214-1220
  • 27 Romeo E, Lops D, Chiapasco M. et al. Therapy of peri-implantitis with resective surgery. A 3-year clinical trial on rough screw-shaped oral implants. Part II: radiographic outcome. Clinical Oral Implants Res 2007; 18: 179-187
  • 28 Romeo E, Ghisolfi M, Murgolo N. et al. Therapy of peri-implantitis with resective surgery. A 3-year clinical trial on rough screw-shaped oral implants. Part I: clinical outcome. Clinical Oral Implants Res 2005; 16: 9-18
  • 29 Smeets R, Henningsen A, Jung O. et al. Definition, etiology, prevention and treatment of peri-implantitis – a review. Head Face Med 2014; 10: 34
  • 30 Kolk A, Handschel J, Drescher W. et al. Current trends and future perspectives of bone substitute materials – from space holders to innovative biomaterials. J Craniomaxillofac Surg 2012; 40: 706-718
  • 31 Fischer J, Kolk A, Wolfart S. et al. Future of local bone regeneration – protein versus gene therapy. J Craniomaxillofacial Surg 2011; 39: 54-64
  • 32 Iezzi G, Degidi M, Scarano A. et al. Anorganic bone matrix retrieved 14 years after a sinus augmentation procedure: a histologic and histomorphometric evaluation. J Periodontol 2007; 78: 2057-2061
  • 33 Araujo MG, Lindhe J. Socket grafting with the use of autologous bone: an experimental study in the dog. Clin Oral Implants Res 2011; 22: 9-13
  • 34 Schwarz F, Sculean A, Bieling K. et al. Two-year clinical results following treatment of peri-implantitis lesions using a nanocrystalline hydroxyapatite or a natural bone mineral in combination with a collagen membrane. J Clin Periodontol 2008; 35: 80-87
  • 35 Schwarz F, Sahm N, Bieling K. et al. Surgical regenerative treatment of peri-implantitis lesions using a nanocrystalline hydroxyapatite or a natural bone mineral in combination with a collagen membrane: a four-year clinical follow-up report. J Clin Periodontol 2009; 36: 807-814
  • 36 Sahrmann P, Attin T, Schmidlin PR. Regenerative treatment of peri-implantitis using bone substitutes and membrane: a systematic review. Clin Implant Dent Relat Res 2011; 13: 46-57
  • 37 Wetzel AC, Vlassis J, Caffesse RG. et al. Attempts to obtain re-osseointegration following experimental peri-implantitis in dogs. Clin Oral Implants Res 1999; 10: 111-119
  • 38 Roos-Jansaker AM, Persson GR, Lindahl C. et al. Surgical treatment of peri-implantitis using a bone substitute with or without a resorbable membrane: a 5-year follow-up. J Clin Periodontol 2014; 41: 1108-1114
  • 39 Daugela P, Cicciù M, Saulacic N. Surgical regenerative treatments for peri-implantitis: meta-analysis of recent findings in a systematic literature review. J Oral Maxillofac Res 2016; 7: e15
  • 40 Schwarz F, Hegewald A, John G. et al. Four-year follow-up of combined surgical therapy of advanced peri-implantitis evaluating two methods of surface decontamination. J Clin Periodontol 2013; 40: 962-967
  • 41 de Waal YC, Raghoebar GM, Huddleston Slater JJ. et al. Implant decontamination during surgical peri-implantitis treatment: a randomized, double-blind, placebo-controlled trial. J Clin Periodontol 2013; 40: 186-195
  • 42 Regev E, Shiff JS, Kiss A. et al. Internal fixation of mandibular angle fractures: a meta-analysis. Plast Reconstr Surg 2010; 125: 1753-1760
  • 43 Danda AK. Comparison of a single noncompression miniplate versus 2 noncompression miniplates in the treatment of mandibular angle fractures: a prospective, randomized clinical trial. J Oral Maxillofac Surg 2010; 68: 1565-1567
  • 44 Hermund NU, Hillerup S, Kofod T. et al. Effect of early or delayed treatment upon healing of mandibular fractures: a systematic literature review. Dental Traumatol 2008; 24: 22-26
  • 45 Schaefer 4th EH, Caterson EJ. Antibiotic selection for open reduction internal fixation of mandible fractures. J Craniofac Surg 2013; 24: 85-88
  • 46 Ghanem WA, Elhayes KA, Saad K. The management of unstable oblique infected mandibular fractures with a 2.3 mm mandibular osteosynthesis reconstruction bone plate. J Craniomaxillofac Surg 2011; 39: 600-605
  • 47 Knepil GJ, Loukota RA. Outcomes of prophylactic antibiotics following surgery for zygomatic bone fractures. J Craniomaxillofac Surg 2010; 38: 131-133
  • 48 Maloney PL, Lincoln RE, Coyne CP. A protocol for the management of compound mandibular fractures based on the time from injury to treatment. J Oral Maxillofac Surg 2001; 59: 879-884
  • 49 Lee HB, Oh JS, Kim SG. et al. Comparison of titanium and biodegradable miniplates for fixation of mandibular fractures. J Oral Maxillofac Surg 2010; 68: 2065-2069
  • 50 Cahill 3rd TJ, Gandhi R, Allori AC. et al. Hardware removal in craniomaxillofacial trauma: a systematic review of the literature and management algorithm. Ann Plast Surg 2015; 75: 572-578
  • 51 Zanotti B, Zingaretti N, Verlicchi A. et al. Cranioplasty: review of materials. J Craniofac Surg 2016; DOI: 10.1097/scs.0000000000003025.
  • 52 Shah AM, Jung H, Skirboll S. Materials used in cranioplasty: a history and analysis. Neurosurg Focus 2014; 36: E19
  • 53 Kimchi G, Stlylianou P, Wohl A. et al. Predicting and reducing cranioplasty infections by clinical, radiographic and operative parameters – a historical cohort study. J Clin Neurosci 2016; 34: 182-186
  • 54 Young RF, Lawner PM. Perioperative antibiotic prophylaxis for prevention of postoperative neurosurgical infections. A randomized clinical trial. J Neurosurg 1987; 66: 701-705
  • 55 Walcott BP, Kwon CS, Sheth SA. et al. Predictors of cranioplasty complications in stroke and trauma patients. J Neurosurg 2013; 118: 757-762
  • 56 Malcolm JG, Rindler RS, Chu JK. et al. Complications following cranioplasty and relationship to timing: a systematic review and meta-analysis. J Clin Neurosci 2016; 33: 39-51
  • 57 Yadla S, Campbell PG, Chitale R. et al. Effect of early surgery, material, and method of flap preservation on cranioplasty infections: a systematic review. Neurosurgery 2011; 68: 1124-1129
  • 58 Conen A, Fux CA, Vajkoczy P. et al. Management of infections associated with neurosurgical implanted devices. Expert Rev Anti Infect Ther 2017; 15: 241-255
  • 59 Brown EM, Edwards RJ, Pople IK. Conservative management of patients with cerebrospinal fluid shunt infections. Neurosurgery 2008; 62 (Suppl. 02) S661-S669