Int J Sports Med 2017; 38(06): 418-425
DOI: 10.1055/s-0043-101910
Physiology & Biochemistry
© Georg Thieme Verlag KG Stuttgart · New York

Effects of Hypertrophy Exercise in Bone Turnover Markers and Structure in Growing Male Rats

Elena Nebot
1  CIBM, IMUDS, Department of Physiology, School of Pharmacy, University of Granada, Spain
2  Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria
,
Virginia A. Aparicio
1  CIBM, IMUDS, Department of Physiology, School of Pharmacy, University of Granada, Spain
3  Department of Public and Occupational Health, EMGO+ Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands
,
Peter Pietschmann
2  Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria
,
Daniel Camiletti-Moirón
1  CIBM, IMUDS, Department of Physiology, School of Pharmacy, University of Granada, Spain
4  Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz, Spain
,
Garyfallia Kapravelou
1  CIBM, IMUDS, Department of Physiology, School of Pharmacy, University of Granada, Spain
,
Reinhold G. Erben
5  Department of Biomedical Sciences, Institute of Physiology, Pathophysiology, and Biophysics, University of Veterinary Medicine, Vienna, Austria
,
Rosario Martínez
1  CIBM, IMUDS, Department of Physiology, School of Pharmacy, University of Granada, Spain
,
Cristina Sánchez-González
1  CIBM, IMUDS, Department of Physiology, School of Pharmacy, University of Granada, Spain
,
Jesús M. Porres
1  CIBM, IMUDS, Department of Physiology, School of Pharmacy, University of Granada, Spain
,
Juan Llopis
1  CIBM, IMUDS, Department of Physiology, School of Pharmacy, University of Granada, Spain
,
María López-Jurado
,
Pilar Aranda
1  CIBM, IMUDS, Department of Physiology, School of Pharmacy, University of Granada, Spain
› Author Affiliations
Further Information

Publication History



accepted after revision 09 January 2017

Publication Date:
07 April 2017 (online)

Abstract

The benefits of exercise on bone density, structure and turnover markers are rather controversial. The present study aimed to examine the effects of hypertrophy exercise (HE) on bone. 20 male Wistar rats were randomly distributed in 2 experimental groups, one performing HE and the other untrained over 12 weeks. Plasma parameters, bone mineral content, bone mineral density (BMD), structure, and trabecular and cortical microarchitecture were measured. Femur Mg content was 12% higher (p<0.001), whereas femur length, dry weight, P content, and aminoterminal propeptides of type I procollagen were lower in the HE group (all, p<0.05). Total BMD and cortical/subcortical BMD were higher (both, p<0.01), whereas total cross-sectional and trabecular areas were lower (both, p<0.001), and cortical area and thickness were lower in the HE (both, p<0.05). Trabecular connectivity density, number, mean density of total and bone volume were higher in the HE (all, p<0.05). Cortical volume fraction and the mean density of total volume of the diaphysis were lower, whereas the cortical volume density was higher in the HE (all, p<0.05). This HE protocol may have beneficial effect on cancellous bone microarchitecture, but it induces low bone formation and is associated with hypogonadism in growing male rats. However, this type of training might be inefficient to maintain appropriate cortical thickness.