Exp Clin Endocrinol Diabetes Rep 2017; 04(01): e1-e4
DOI: 10.1055/s-0043-101823
Short Communication
© Georg Thieme Verlag KG Stuttgart · New York

Frequency of Genital Infections According to Body Mass Index in Dapagliflozin-treated Patients with Type 2 Diabetes Mellitus

Gottfried Rudofsky1, Tanja Haenni1, John Xu2, Eva Johnsson3
  • 1Department of Endocrinology, Diabetes and Clinical Nutrition, Kantonsspital, Olten, Switzerland
  • 2AstraZeneca, Gaithersburg, MD, USA
  • 3AstraZeneca, Gothenburg, Mölndal, Sweden
Further Information

Publication History

received 25 August 2016
revised 17 November 2016

accepted 02 December 2016

Publication Date:
16 March 2017 (eFirst)

Abstract

Aims

Genital infections are associated with sodium glucose co-transporter 2 inhibitors such as dapagliflozin. Since patients with Type 2 diabetes are at increased risk of genital infections, and obesity is a risk factor for infections, obese patients with Type 2 diabetes could be more susceptible to genital infections when treated with sodium glucose co-transporter 2 inhibitors. This pooled dataset assessed the frequency of genital infections according to baseline body mass index in patients treated with dapagliflozin 10 mg.

Methods

Data were pooled from 13 studies of up to 24 weeks’ duration (dapagliflozin N=2 360; placebo N=2 295). Frequency of genital infections was compared between three body mass index subgroups (<30, ≥30−< 35 and ≥35 kg/m2).

Results

Genital infections were reported in 130 (5.5%) patients receiving dapagliflozin and 14 (0.6%) patients receiving placebo; none of which were serious. Genital infections were more common in women (84/130 [64.6%]) than in men (46/130 [35.4%]) treated with dapagliflozin. In the body mass index < 30, ≥ 30−< 35 and ≥ 35 kg/m2 dapagliflozin-treated subgroups, 38/882 (4.3%), 47/796 (5.9%) and 45/682 (6.6%) patients presented with genital infections, respectively.

Conclusion

Although the frequency was low overall and relatively similar between subgroups, there was a trend towards an increase in genital infections in patients with a higher body mass index. This trend is unlikely to be clinically relevant or to affect suitability of dapagliflozin as a treatment option for obese patients with Type 2 diabetes, but rather should influence advice and counselling of overweight patients on prevention and treatment of genital infections.

Supplementary Material