Tenosynovitis Evaluation Using Image Fusion and B-Flow – A Pilot Study on New Imaging Techniques in Rheumatoid Arthritis Patients

Mads Ammitzbøll-Danielsen; Daniel Glinatsi; Søren Torp-Pedersen; Jacob M. Møller; Esperanza Naredo; Mikkel Ostergaard; Lene Terslev

doi:10.1055/s-0043-101228

Ultraschall in der Medizin - European Journal of Ultrasound, Inhaltsverzeichnis

Ultraschall Med 2017; 38(03): 285-293
DOI: 10.1055/s-0043-101228

Original Article

Tenosynovitis Evaluation Using Image Fusion and B-Flow – A Pilot Study on New Imaging Techniques in Rheumatoid Arthritis Patients

Beurteilung der Tenosynovitis mittels Bildfusion und B-Flow – Eine Pilotstudie zu neuen bildgebenden Verfahren bei Patienten mit rheumatoider Arthritis

Mads Ammitzbøll-Danielsen

¹Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen, Denmark

²Department of Clinical Medicine, Copenhagen Universitet, Copenhagen, Denmark

,

Daniel Glinatsi

¹Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen, Denmark

²Department of Clinical Medicine, Copenhagen Universitet, Copenhagen, Denmark

,

Søren Torp-Pedersen

³Department of Radiology, Rigshospitalet, Glostrup, Copenhagen, Denmark

,

Jacob M. Møller

⁴Department of Radiology, Herlev-Gentofte Hospital, Copenhagen, Denmark

,

Esperanza Naredo

⁵Department of Rheumatology, Hospital General Universitario Gregorio Marañón and Universidad Complutense, Madrid, Spain

⁶Department of Rheumatology, Joint and Bone Research Unit, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain

,

Mikkel Ostergaard

¹Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen, Denmark

²Department of Clinical Medicine, Copenhagen Universitet, Copenhagen, Denmark

,

Lene Terslev

¹Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen, Denmark

› Institutsangaben

Abstract

Aim The aim of this study was to compare the assessment of tenosynovitis by ultrasound (US) and magnetic resonance imaging (MRI) using the image fusion technique and to investigate whether US B-flow imaging (BFI) is an alternative to Doppler US when assessing tenosynovitis.

Materials and Methods 15 patients with rheumatoid arthritis (RA) had US-verified tenosynovitis in the wrist/hand. An MRI was performed of the wrist/hand with subsequent repeated US and image fusion. Images were compared in three steps: 1. Visual image comparison, 2. Quantitative measurement of transverse areas of the affected tendon and tendon sheath, using two tendon measures on MRI, area 1 and area 2, excluding and including partial volume artifacts, respectively, 3. Assessment using the OMERACT semi-quantitative scoring systems for US and MRI. Furthermore, BFI was assessed as: 0: No flow, 1: Focal flow, 2: Multifocal flow, 3: Diffuse flow, in the tendon sheath.

Results The median areas on US and MRI (areas 1 and 2) were 0.16 cm² (25;75 pctl: 0.10; 0.25), 0.9 cm² (0.06; 0.18) and 0.13 cm² (0.10; 0.25), respectively, for included tendons and 0.18 cm² (0.13; 0.26), 0.27 cm² (0.20; 0.45) and 0.23 cm² (0.16; 0.40) for tendon sheaths. No statistically significant difference was found between US tendon area and MRI tendon area 2 (Wilcoxon’s test; p = 0.47). Overall, the agreement between grayscale and color Doppler (CD) US and MRI tenosynovitis visualization and scoring was good, but not between CD and BFI.

Conclusion US and MRI have high agreement using image fusion for the assessment of tenosynovitis when partial volume artifacts are taken into account. BFI is not an alternative to CD for the measurement of slow flow in tenosynovitis.

Zusammenfassung

Ziel Das Ziel dieser Studie war es, die Beurteilung der Tenosynovitis mittels Ultraschall (US) und Magnetresonanztomografie (MRT) mittels Bildfusionsverfahren zu vergleichen und zu untersuchen, ob das sonografische B-Flow-Imaging (BFI) eine Alternative zur Dopplersonografie bei der Einstufung der Tenosynovitis darstellt.

Material und Methoden 15 Patienten mit rheumatoider Arthritis (RA) hatten eine sonografisch bestätigte Sehnenscheidenentzündung des Handgelenks/der Hand. Eine MRT wurde am Handgelenk/der Hand durchgeführt gefolgt von wiederholten US-Untersuchungen und Bildfusion.

Ergebnisse Die medianen Bereiche im US und MRT (Regionen 1 und 2) betrugen für eingeschlossene Sehen 0,16 cm² (25; 75 Perz.: 0,10; 0,25), 0,9 cm² (0,06; 0,18) und 0,13 cm² (0,10; 0,25), und für Sehnenscheiden 0,18 cm² (0,13; 0,26), 0,27 cm² (0,20; 0,45) und 0,23 cm² (0,16; 0,40). Kein statistisch signifikanter Unterschied wurde zwischen dem Sehnenbereich im US und der Sehnenregion 2 in der MRT beobachtet (Wilcoxon-Test; p = 0,47).

Schlussfolgerung Insgesamt ergab sich eine gute Übereinstimmung zwischen Graustufen- und Farbdoppler (CD)-US und MRT bei der Darstellung der Tenosynovitis und das Scoring war gut. Allerdings traf dies für CD und BFI nicht zu. Schlussfolgerung: US und MRT zeigen ein hohe Übereinstimmung bei der Anwendung der Bildfusion zur Bewertung der Tenosynovitis, wenn partielle Volumenartefakte mit berücksichtigt werden. BFI ist keine Alternative zum CD bei der Bestimmung des langsamen Flusses bei Tenosynovitis.

Key words

tendons - ultrasound - arthritides - MR imaging - ultrasound Doppler

Volltext

Referenzen

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