Update on Hepatobiliary Plasticity

Minwook Kim; Fatima Rizvi; Donghun Shin; Valerie Gouon-Evans

doi:10.1055/s-0042-1760306

Seminars in Liver Disease, Table of Contents

CC BY-NC-ND 4.0 · Semin Liver Dis 2023; 43(01): 013-023
DOI: 10.1055/s-0042-1760306

Review Article

Update on Hepatobiliary Plasticity

Minwook Kim^*

¹Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

,

Fatima Rizvi^*

²Department of Medicine, Gastroenterology Section, Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, Massachusetts

,

Donghun Shin

¹Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

,

Valerie Gouon-Evans

²Department of Medicine, Gastroenterology Section, Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, Massachusetts

› Author Affiliations

Abstract

The liver field has been debating for decades the contribution of the plasticity of the two epithelial compartments in the liver, hepatocytes and biliary epithelial cells (BECs), to derive each other as a repair mechanism. The hepatobiliary plasticity has been first observed in diseased human livers by the presence of biphenotypic cells expressing hepatocyte and BEC markers within bile ducts and regenerative nodules or budding from strings of proliferative BECs in septa. These observations are not surprising as hepatocytes and BECs derive from a common fetal progenitor, the hepatoblast, and, as such, they are expected to compensate for each other's loss in adults. To investigate the cell origin of regenerated cell compartments and associated molecular mechanisms, numerous murine and zebrafish models with ability to trace cell fates have been extensively developed. This short review summarizes the clinical and preclinical studies illustrating the hepatobiliary plasticity and its potential therapeutic application.

Keywords

hepatocyte plasticity - cholangiocyte plasticity - biliary epithelial cell plasticity - liver progenitor cells - liver regeneration

Full Text

References

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