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CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2022; 14(04): 135-144
DOI: 10.1055/s-0042-1760223
Original Article

Effect of Solvent Extracts of Tephrosia vogelii Leaves and Stem on Lipid Profile of Poloxamer 407-Induced Hyperlipidemic Rats

Inalegwu Bawa
1   Department of Biochemistry, Faculty of Basic Medical Sciences, Federal University of Health Sciences, Otukpo, Benue State, Nigeria
,
Daniel Ejim Uti 
1   Department of Biochemistry, Faculty of Basic Medical Sciences, Federal University of Health Sciences, Otukpo, Benue State, Nigeria
,
Matthew Ocheleka Itodo
1   Department of Biochemistry, Faculty of Basic Medical Sciences, Federal University of Health Sciences, Otukpo, Benue State, Nigeria
,
Grace Ufedo Umoru
2   Department of Biochemistry, College of Science, Evangel University Akaeze, Abakaliki, Ebonyi State, Nigeria
,
Suleiman Zakari 
3   Molecular Biology Laboratory, Department of Biochemistry, Covenant University, Ota, Ogun State, Nigeria
,
Uket Nta Obeten
4   Department of Chemistry/Biochemistry and Molecular Biology, Alex Ekwueme Federal University, Ndufu- Alike Ikwo, Abakaliki, Ebonyi State, Nigeria
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Funding This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
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Abstract

Introduction There are claims by traditional medicine practitioners in Nigeria and valuable scientific reports that the leaves of Tephrosia vogelii (TV) hook are used for the treatment of various diseases; however, there is paucity of information on it used in the management of cardiovascular complications despite the rich presence of phytochemicals. This study aimed at investigating effects of solvents extracts of TV leaves and stem on lipid profile of poloxamer 407-induced hyperlipidemic rats.

Materials and Methods Varying doses of the solvent extracts (water, ethanol, and acetic acid) of plant material were administered to experimental animals (Albino Wistar rats) induced with hyperlipidemia using poloxamer 407 (P-407).

Results The results of the phytochemical screening of leaves and stem revealed the presence of alkaloids, saponins, phlobatannins, and flavonoids in powdered sample of leaves and stem of TV. Aqueous extract of the leaves had the highest yield (18.21 ± 1.12%), while acetic acid extract of stem had the lowest yield (7.21 ± 1.21%). The cholesterol and triacylglycerol level of rats induced with P-407 was significantly (p≤0.05) higher than normal rats. This study showed that aqueous extract at 50mg/kg body weight significantly (p≤0.05) lower cholesterol, low-density lipoprotein, very low-density lipoprotein, and triacylglycerol levels. Indices of cardiovascular function atherogenic coefficient, atherogenic index, coronary risk index, and cardioprotective index were positively modulated by the treatment.

Conclusion The study indicated that the aqueous leaves extract of TV possesses antihyperlipidemic effects and may explains why it has been found to be useful in the management of cardiovascular diseases by traditional medicine practitioners.

Keywords

Tephrosia vogelii leaves - cardiovascular function - hyperlipidemia - phytochemicals - poloxamer 407

Availability of Data

Available from the corresponding authors on request.


Authors' Contributions

IB and DEU conceived and designed the study. MOI, SZ, and UNO performed literature research. IB wrote the manuscript. GUU and DEU read, edited, and revised the manuscript for intellectual content. All authors have read and approved the final manuscript.


Ethical Approval

This study followed the Convention on Trade in Endangered Species of Wild Fauna and Flora. Furthermore, the study was approved by the Department of Biochemistry Ethical Committee on Research, Innovation and Institutional Ethical Committee on animal's right (FUHSO/ET/BCH/22/001).




Publikationsverlauf

Artikel online veröffentlicht:
07. Februar 2023

© 2023. The Libyan Authority of Scientific Research and Technology and the Libyan Biotechnology Research Center. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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