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CC BY 4.0 · Indian Journal of Neurotrauma 2023; 20(01): 004-010
DOI: 10.1055/s-0042-1759853
DOI: 10.1055/s-0042-1759853
Review Article
Biomarkers in Traumatic Brain Injuries: Narrative Review
Abstract
Traumatic brain injury (TBI) is a multistep interaction of brain antigens, cytokine-mediated humeral, and cellular immune reactions. Because of the limitations of clinical and radiological evaluation in TBI, there has been a considerable advancement toward the need for developing biomarkers that can predict the severity of TBI. Blood-based brain biomarkers hold the potential to predict the absence of intracranial injury and thus decrease unnecessary brain computed tomographic scanning. Various biomarkers have been studied that detects neuronal, axonal, and blood–brain barrier integrity. Biomarkers are still under investigation and hold promise in the future evaluation of TBI patients. They can be used for grading as well as a prognostication of head injury.
Note
This work is part of a project titled “Development of a serum biomarker panel for predicting outcome of traumatic brain injuries,” Funded by ICMR. ICMR/007/306/2018/01056.
Publication History
Article published online:
23 December 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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