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CC BY 4.0 · Indian J Med Paediatr Oncol
DOI: 10.1055/s-0042-1759506
Case Report with Review of Literature

Hypercalcemia in Chronic Myeloid Leukemia: An Unusual Presentation

Autoren

  • Khushboo Agarwal 

    1   Department of Oncolgy, Mahatma Gandhi Medical College, Jaipur, Rajasthan, India

  • Naveen Gupta 

    1   Department of Oncolgy, Mahatma Gandhi Medical College, Jaipur, Rajasthan, India

  • Hemant Malhotra 

    1   Department of Oncolgy, Mahatma Gandhi Medical College, Jaipur, Rajasthan, India
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Abstract

Hypercalcemia in CML is an unusual paraneoplastic syndrome and is associated with worse prognosis and reduced survival. It usually seen in blast crisis or accelerated phase but can also indicate bony infiltration by cancer cells. Multiple mechanisms can be involved in a patient. We present a case of hypercalcemia in CML in chronic phase without bony infiltration or increased parathormone levels. Increased calcium levels may also be first indication of tyrosine kinase inhibitor resistance. Patient was managed symptomatically with subsequent change of the drug for managing CML. He is currently stable at six months follow-up. Therefore, careful evaluation of the cause of hypercalcemia is necessary for appropriate management.

Keywords

hypercalcemia - CML - tyrosine kinase resistance

Note

Informed consent was taken from the patient.




Publikationsverlauf

Artikel online veröffentlicht:
24. Januar 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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