Planta Med 2022; 88(15): 1503
DOI: 10.1055/s-0042-1759165
Poster Session I

Phytochemical analysis and biological properties of Heliotropium procumbens from Panama

K-M Ozntamar-Pouloglou
1   Lab. of Pharmacognosy & Chemistry of Natural Products, Department of Pharmacy, NKUA, Zografou 15771, Athens, Greece, Athens, Greece
,
T Mroczek
2   Dept of Pharmacognosy with Medicinal Plant Laboratory Unit, Medical University, Lublin 20093, Poland, Lublin, Poland
,
A Cheilari
1   Lab. of Pharmacognosy & Chemistry of Natural Products, Department of Pharmacy, NKUA, Zografou 15771, Athens, Greece, Athens, Greece
,
G Zengin
3   Dept of Biology, Science Faculty, Selcuk University, University Campus 42130, Konya, Turkey, Konya, Turkey
,
K Graikou∗
1   Lab. of Pharmacognosy & Chemistry of Natural Products, Department of Pharmacy, NKUA, Zografou 15771, Athens, Greece, Athens, Greece
,
C Ganos
1   Lab. of Pharmacognosy & Chemistry of Natural Products, Department of Pharmacy, NKUA, Zografou 15771, Athens, Greece, Athens, Greece
,
E-F Varvouni
1   Lab. of Pharmacognosy & Chemistry of Natural Products, Department of Pharmacy, NKUA, Zografou 15771, Athens, Greece, Athens, Greece
,
G-A Karikas
4   Dept of Biomedical Sciences, University of West Attica, Athens 12243, Greece, Athens, Greece
,
I Chinou
1   Lab. of Pharmacognosy & Chemistry of Natural Products, Department of Pharmacy, NKUA, Zografou 15771, Athens, Greece, Athens, Greece
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Heliotropium (Boraginaceae) is a plant genus widespread, used in folk medicine for its healing properties (against inflammation, rheumatism, skin disorders etc), known source of pyrrolizidine alkaloids (PAs) and their N-oxides (PANOs), and phenolic metabolites [1].

In the framework of our phytochemical studies on Boraginaceae plants [2], we report herein the phytochemical analysis of H. procumbens aerial parts growing in Panama.

The LC-MS analysis revealed the presence of PANOs, among which three new natural products: helifoline, 9-angleloylheliotridine and hydroxy-platynecine as well as the known 7-angeloylheliotridine, senecionine, europine, lycopsamine and Intermedine. Additionally, the PAs riddelin, europine, lycopsamine, hydroxyplatynecine together with N, Ν-diferuylo-spermidine and several amino-alcohols were identified.

Moreover, 18 phenolic metabolites were identified (LC-MS), comprising of 5 flavonoids, 3 caffeic acid derivatives and 10 benzoic and cinnamic acid derivatives, among which luteolin-7-glucoside, rosmarinic acid and lithospermic acid have been isolated and structurally determined (NMR).

Antioxidant properties of methanol (ME) and water (WE) extracts were assessed via eight different assays (TPC, TFC, DPPH, ABTS, CUPRAC, FRAP, Metal chelating and Phospholybdenum). The extracts displayed considerable DPPH and ABTS scavenging activity and noticeable reducing power in CUPRAC and FRAP.

The inhibitory activity of the extracts was determined [2] against cholinesterases (AChE, BChE), agents with important role in the function of the nervous system, against α-amylase and α-glucosidase, a useful strategy for the management of obesity and diabetes, as well as against tyrosinase, a skin whitening factor.

H. procubens could be considered potential sources of bioactive metabolites exploited for further research or potential applications.



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Artikel online veröffentlicht:
12. Dezember 2022

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  • References

  • 1 Ghori MK, Ghaffari MA, Nawaz S. et al. Ethnopharmacological Phytochemical and Pharmacognostic Potential of Genus Heliotropium L. 2016; 22.
    PubMed
  • 2 Varvouni EF, Zengin G, Graikou K. et al. Phytochemical analysis and biological evaluation of the aerial parts from Symphytum anatolicum Boiss. and Cynoglottis barrelieri (All.) Vural & Kit Tan (Boraginaceae). Biochem Syst Ecol 2020; 92: 104128
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