The study of choleretic activity of Artemisia L. herb extracts

Artemisia L. species are used in medicine for the appetite stimulation and as choleretic, antimalarial, antitumor, anti-inflammatory and antimicrobial agents. These pharmacological properties of Artemisia L. herb are due to its diverse chemical composition [1], [2], [3].

The aim of the research was to study choleretic properties of Artemisia absinthium and Artemisia vulgaris standardized extracts [4].

To investigate the dose-dependence of the choleretic effect we used the extracts in doses: 25, 50 and 100 mg/kg body weight of rats. The strongest choleretic effect was observed for Artemisia absinthium extract at a dose of 50 mg/kg; bile secretion increased by 64.6%, which is 1.64 times higher than in the control group of animals,and exceeded the comparison drug “Flamin” by 19.2%.

By decreasing the percentage increase in the average rate of bile secretion, the studied drugs are arranged as follows: Artemisia absinthium extract at a dose of 50 mg/kg (64.6%) → “Flamin” at a dose of 50 mg/kg (45.4%) → extract Artemisia absinthium at a dose of 100 mg/kg (35.4%) → Artemisia absinthium extract at a dose of 25 mg/kg (27.3%).

Administration of Artemisia vulgaris extracts at doses of 25, 50 and 100 mg/kg body weight contributed to a moderate stimulation of bile secretion in experimental animals, but the excretion intensity was lower than comparison drug “Flamin”.

Thus, pharmacological studies prove the viability of Artemisia absinthium herb extract introduction for the treatment of the hepatobiliary system diseases.

Publikationsverlauf

Artikel online veröffentlicht:
12. Dezember 2022

• References

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