Polyprenylated aromatic acylphloroglucinols from Hypericum cordifolium Choisy

Hypericum represents the largest genus of Hypericaceae and species are distributed almost all over the world. Hypericum perforatum L. is the medicinally most used species in Europe, and its extracts showed anti-depressant, anti-inflammatory and anti-bacterial effects (Barnes et al. 2001). Nevertheless, various Hypericum species are used in traditional medicine of other cultures with further indications (Zhang et al. 2020) and thus the investigation of secondary metabolite profiles and therapeutic potential of other unexplored Hypericum species is still important.

As part of our research a dichloromethane extract of the aerial parts from Hypericum cordifolium CHOISY a species native to Nepal was phytochemically examined. H. cordifolium is traditionally used for the treatment of menstrual disorder, backache, dislocation of bone, fever, and diarrhea (Basyal und Bhandari 2020). The extract was fractionated by open CC, CPC and semi-preparative HPLC techniques to gain 4 known acylphloroglucinols (Uralione D, Clusiachromene C, Clusiacitran A, Clusiacitran B) previously isolated from Clusia multifolia and Hypericum uralum (Gonzalez et al. 1995; Fun et al. 2006; Zhou et al. 2016), and 4 hitherto unknown polyprenylated phloroglucinols (1 – 4, Fig. 1) all showing aromatic acyl substitution. The structures were elucidated with 1D and 2D NMR spectroscopy together with high-resolution electrospray ionization mass spectrometry. All compounds will be tested for antibacterial activity.

Publikationsverlauf

Artikel online veröffentlicht:
12. Dezember 2022

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