Planta Med 2022; 88(15): 1436
DOI: 10.1055/s-0042-1758998
Poster Session I

Phytochemical screening of Gentiana purpurea, an important Norwegian medicinal plant

Authors

  • L Zhang

    Section for Pharmaceutical Chemistry, Department of Pharmacy, University of Oslo, Oslo, Norway

  • L Sandvik

    Section for Pharmaceutical Chemistry, Department of Pharmacy, University of Oslo, Oslo, Norway

  • H Hoel

    Section for Pharmaceutical Chemistry, Department of Pharmacy, University of Oslo, Oslo, Norway

  • K E Malterud

    Section for Pharmaceutical Chemistry, Department of Pharmacy, University of Oslo, Oslo, Norway

  • K Inngjerdingen

    Section for Pharmaceutical Chemistry, Department of Pharmacy, University of Oslo, Oslo, Norway

  • H Wangensteen∗

    Section for Pharmaceutical Chemistry, Department of Pharmacy, University of Oslo, Oslo, Norway
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Gentiana purpurea L. (Gentianaceae family) was one of the most important medicinal plants in Norway in the 19th and 20th centuries, both for veterinary and human use. Indications were all kind of stomach diseases, especially diarrhea, but also chest diseases such as bronchitis, and to treat coughing and the cold. The roots are known for the intense bitterness, which can be explained by the high content of secoirioids. Secoiridoids, such as gentiopicroside and amarogentin have previously been identified in the plant [1], however a detailed overview of the metabolites in the traditional preparations that were commonly used has not previously been described. The aim of the presented study was to perform a phytochemical screening of water and ethanol extracts of G. purpurea.

The crude extracts were applied to a Diaion HP-20 column and eluted with water and methanol. The methanol fractions were subjected to C18 flash chromatography, Sephadex LH-20 and preparative HPLC to obtain pure compounds. NMR and MS were used for structure elucidation. Isolated compounds included secoiridoid glucosides, flavonoids, a lignan, and other phenolic compounds, and represent both new natural products and new compounds for G. purpurea.

We have no conflict of interest.



Publication History

Article published online:
12 December 2022

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