Clin Colon Rectal Surg 2024; 37(02): 085-089
DOI: 10.1055/s-0042-1758823
Review Article

Surgical and Interventional Management of Lung Metastasis: Surgical Assessment, Resection, Ablation, Percutaneous Interventions

Amalia J. Stefanou
1   Gastrointestinal Oncology, Surgical Oncology, Moffitt Cancer Center, Tampa, Florida
› Institutsangaben

Abstract

The lungs are the second most common site of metastases for colorectal cancer after the liver. Pulmonary metastases can be identified at the time of diagnosis of the primary tumor, or metachronously. About 20% of patients with colorectal cancer will develop pulmonary metastases. The best options for treatment include a multidisciplinary treatment approach consisting of surgical resection whenever possible, and chemotherapy. Surgical options most often include minimally invasive segmentectomy or wedge resection, while patients unable to have surgery may benefit from radio frequency ablation or radiation treatment. Prognosis is dependent on preoperative carcinoembryonic antigen level, number, and location of metastatic lesions, and resectability of primary tumor. Overall, pulmonary metastases are best treated by complete resection whenever possible.



Publikationsverlauf

Artikel online veröffentlicht:
29. November 2022

© 2022. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 
  • References

  • 1 Parnaby CN, Bailey W, Balasingam A. et al. Pulmonary staging in colorectal cancer: a review. Colorectal Dis 2012; 14 (06) 660-670
  • 2 Ikoma N, You YN, Bednarski BK. et al. Impact of recurrence and salvage surgery on survival after multidisciplinary treatment of rectal cancer. J Clin Oncol 2017; 35 (23) 2631-2638
  • 3 Kim HK, Cho JH, Lee HY, Lee J, Kim J. Pulmonary metastasectomy for colorectal cancer: how many nodules, how many times?. World J Gastroenterol 2014; 20 (20) 6133-6145
  • 4 Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin 2015; 65 (01) 5-29
  • 5 Pfannschmidt J, Dienemann H. Surgical treatment of oligometastatic non-small cell lung cancer. Lung Cancer 2010; 69 (03) 251-258
  • 6 Elias D, Liberale G, Vernerey D. et al. Hepatic and extrahepatic colorectal metastases: when resectable, their localization does not matter, but their total number has a prognostic effect. Ann Surg Oncol 2005; 12 (11) 900-909
  • 7 Kato Y, Shigeta K, Okabayashi K. et al. Lymph node metastasis is strongly associated with lung metastasis as the first recurrence site in colorectal cancer. Surgery 2021; 170 (03) 696-702
  • 8 Gaitanidis A, Machairas N, Alevizakos M, Tsalikidis C, Tsaroucha A, Pitiakoudis M. Predictive nomograms for synchronous liver and lung metastasis in colon cancer. J Gastrointest Cancer 2020; 51 (03) 925-931
  • 9 Nagtegaal ID, Knijn N, Hugen N. et al. Tumor deposits in colorectal cancer: improving the value of modern staging-a systematic review and meta-analysis. J Clin Oncol 2017; 35 (10) 1119-1127
  • 10 Watanabe K, Saito N, Sugito M, Ito M, Kobayashi A, Nishizawa Y. Predictive factors for pulmonary metastases after curative resection of rectal cancer without preoperative chemoradiotherapy. Dis Colon Rectum 2011; 54 (08) 989-998
  • 11 Qi H, Fan W. Value of ablation therapy in the treatment of lung metastases. Thorac Cancer 2018; 9 (02) 199-207
  • 12 Simmonds PC. Colorectal Cancer Collaborative Group. Palliative chemotherapy for advanced colorectal cancer: systematic review and meta-analysis. BMJ 2000; 321 (7260): 531-535
  • 13 Zhang GQ, Taylor JP, Stem M. et al. Aggressive multimodal treatment and metastatic colorectal cancer survival. J Am Coll Surg 2020; 230 (04) 689-698
  • 14 Benson III AB, Venook AP, Bekaii-Saab T. et al; National Comprehensive Cancer Network. Colon cancer, version 3.2014. J Natl Compr Canc Netw 2014; 12 (07) 1028-1059
  • 15 Stewart CL, Warner S, Ito K. et al. Cytoreduction for colorectal metastases: liver, lung, peritoneum, lymph nodes, bone, brain. When does it palliate, prolong survival, and potentially cure?. Curr Probl Surg 2018; 55 (09) 330-379
  • 16 Aberg T, Malmberg KA, Nilsson B, Nöu E. The effect of metastasectomy: fact or fiction?. Ann Thorac Surg 1980; 30 (04) 378-384
  • 17 Hadden WJ, de Reuver PR, Brown K, Mittal A, Samra JS, Hugh TJ. Resection of colorectal liver metastases and extra-hepatic disease: a systematic review and proportional meta-analysis of survival outcomes. HPB (Oxford) 2016; 18 (03) 209-220
  • 18 Jegatheeswaran S, Satyadas T, Sheen AJ, Treasure T, Siriwardena AK. Thoracic surgical management of colorectal lung metastases: a questionnaire survey of members of the Society for Cardiothoracic Surgery in Great Britain and Ireland. Ann R Coll Surg Engl 2013; 95 (02) 140-143
  • 19 Internullo E, Cassivi SD, Van Raemdonck D, Friedel G, Treasure T, Group EPMW. ESTS Pulmonary Metastasectomy Working Group. Pulmonary metastasectomy: a survey of current practice amongst members of the European Society of Thoracic Surgeons. J Thorac Oncol 2008; 3 (11) 1257-1266
  • 20 Prenafeta Claramunt N, Hwang D, de Perrot M. et al. Incidence of ipsilateral side recurrence after open or video-assisted thoracic surgery resection of colorectal lung metastases. Ann Thorac Surg 2020; 109 (05) 1591-1597
  • 21 Shiono S, Okumura T, Boku N. et al. Outcomes of segmentectomy and wedge resection for pulmonary metastases from colorectal cancer. Eur J Cardiothorac Surg 2017; 51 (03) 504-510
  • 22 Papamichael D, Audisio RA, Glimelius B. et al. Treatment of colorectal cancer in older patients: International Society of Geriatric Oncology (SIOG) consensus recommendations 2013. Ann Oncol 2015; 26 (03) 463-476
  • 23 Barone M, Prioletta M, Di Nuzzo D, Cipollone G, Camplese P, Mucilli F. Pulmonary metastasectomy in elderly colorectal cancer patients: a retrospective single center study. Updates Surg 2016; 68 (04) 357-367
  • 24 Bölükbas S, Sponholz S, Kudelin N, Eberlein M, Schirren J. Risk factors for lymph node metastases and prognosticators of survival in patients undergoing pulmonary metastasectomy for colorectal cancer. Ann Thorac Surg 2014; 97 (06) 1926-1932
  • 25 Call S, Rami-Porta R, Embún R. et al. Impact of inappropriate lymphadenectomy on lung metastasectomy for patients with metastatic colorectal cancer. Surg Today 2016; 46 (04) 471-478
  • 26 Zhong J, Palkhi E, Ng H. et al. Long-term outcomes in percutaneous radiofrequency ablation for histologically proven colorectal lung metastasis. Cardiovasc Intervent Radiol 2020; 43 (12) 1900-1907
  • 27 Ahmed KA, Fulp WJ, Berglund AE. et al. Differences between colon cancer primaries and metastases using a molecular assay for tumor radiation sensitivity suggest implications for potential oligometastatic SBRT patient selection. Int J Radiat Oncol Biol Phys 2015; 92 (04) 837-842
  • 28 Jingu K, Matsushita H, Yamamoto T. et al. Stereotactic radiotherapy for pulmonary oligometastases from colorectal cancer: a systematic review and meta-analysis. Technol Cancer Res Treat 2018; 17: 1533033818794936
  • 29 Von Einem JC, Stintzing S, Modest DP, Wiedemann M, Fürweger C, Muacevic A. Frameless single robotic radiosurgery for pulmonary metastases in colorectal cancer patients. Cureus 2020; 12 (03) e7305
  • 30 Muacevic A, Drexler C, Wowra B. et al. Technical description, phantom accuracy, and clinical feasibility for single-session lung radiosurgery using robotic image-guided real-time respiratory tumor tracking. Technol Cancer Res Treat 2007; 6 (04) 321-328
  • 31 Rodler S, Götz M, Mumm JN. et al. Image-guided robotic radiosurgery for the treatment of lung metastases of renal cell carcinoma-a retrospective, single center analysis. Cancers (Basel) 2022; 14 (02) 356
  • 32 Bellier J, De Wolf J, Hebbar M. et al. Repeated resections of hepatic and pulmonary metastases from colorectal cancer provide long-term survival. World J Surg 2018; 42 (04) 1171-1179
  • 33 Hachimaru A, Maeda R, Suda T, Takagi Y. Repeat pulmonary resection for recurrent lung metastases from colorectal cancer: an analysis of prognostic factors. Interact Cardiovasc Thorac Surg 2016; 22 (06) 826-830
  • 34 Jarabo JR, Gómez AM, Calatayud J. et al; Spanish Group of Lung Metastases of Colo-Rectal Cancer of the Spanish Society of Pneumology and Thoracic Surgery (GECMP-CCR-SEPAR). Combined hepatic and pulmonary metastasectomies from colorectal carcinoma. data from the Prospective Spanish Registry 2008-2010. Arch Bronconeumol (Engl Ed) 2018; 54 (04) 189-197 (Engl Ed)
  • 35 Yahagi M, Tsuruta M, Hasegawa H. et al. Smoking is a risk factor for pulmonary metastasis in colorectal cancer. Colorectal Dis 2017; 19 (09) O322-O328
  • 36 Hwang M, Jayakrishnan TT, Green DE. et al. Systematic review of outcomes of patients undergoing resection for colorectal liver metastases in the setting of extra hepatic disease. Eur J Cancer 2014; 50 (10) 1747-1757
  • 37 Andres A, Mentha G, Adam R. et al. Surgical management of patients with colorectal cancer and simultaneous liver and lung metastases. Br J Surg 2015; 102 (06) 691-699
  • 38 Merkel S, Weber K, Croner RS. et al. Distant metastases in colorectal carcinoma: a proposal for a new M1 subclassification. Eur J Surg Oncol 2016; 42 (09) 1337-1342
  • 39 Meimarakis G, Spelsberg F, Angele M. et al. Resection of pulmonary metastases from colon and rectal cancer: factors to predict survival differ regarding to the origin of the primary tumor. Ann Surg Oncol 2014; 21 (08) 2563-2572
  • 40 Park HS, Jung M, Shin SJ. et al. Benefit of adjuvant chemotherapy after curative resection of lung metastasis in colorectal cancer. Ann Surg Oncol 2016; 23 (03) 928-935
  • 41 Schweiger T, Nikolowsky C, Graeter T. et al. Increased lymphangiogenesis in lung metastases from colorectal cancer is associated with early lymph node recurrence and decreased overall survival. Clin Exp Metastasis 2016; 33 (02) 133-141