CC BY-NC-ND 4.0 · J Lab Physicians 2023; 15(02): 224-229
DOI: 10.1055/s-0042-1758667
Original Article

Study of Hemato-morphological Features in Neuroblastoma Infiltrating Marrow

Anurag Singh
1   Department of Pathology, King George Medical University, Lucknow, Uttar Pradesh, India
Shalini Rawat
1   Department of Pathology, King George Medical University, Lucknow, Uttar Pradesh, India
Geeta Yadav
1   Department of Pathology, King George Medical University, Lucknow, Uttar Pradesh, India
1   Department of Pathology, King George Medical University, Lucknow, Uttar Pradesh, India
Shailendra Prasad Verma
2   Department of Clinical Hematology, King George Medical University, Lucknow, Uttar Pradesh, India
Uma S. Singh
1   Department of Pathology, King George Medical University, Lucknow, Uttar Pradesh, India
› Author Affiliations
Funding None.


Objective Neuroblastoma typically affects children within the first 5 years of life and accounts for 10% of all pediatric malignancies. Neuroblastoma at onset may manifest as a localized or metastatic illness. The aim of this study was to identify hematomorphological features in neuroblastoma infiltrating marrow as well as to ascertain the prevalence of bone marrow infiltration in neuroblastoma.

Materials and Methods This retrospective study included newly diagnosed 79 cases of neuroblastoma, which were referred for bone marrow examination for the staging of the disease. Medical records were retrieved to acquire hematomorphological findings of peripheral blood and bone marrow smears. Statistical Package for Social Sciences, IBM Inc., USA, version 21.0 was used to analyze the data.

Results The interquartile age range of neuroblastoma cases was 24.0 to 72.0 months (median = 48 months) with a male to female ratio of 2.7:1. Also, 55.6% (44/79) of cases in the study population showed evidence of marrow infiltration. The bone marrow infiltration was significantly linked to thrombocytopenia (p = 0.043) and nucleated red blood cells (p = 0.003) in peripheral blood. The bone marrow smears of cases with infiltration showed a significant shift to the left in the myeloid series (p = 0.001) and an increased number of erythroid cells (p = 0.001).

Conclusion For neuroblastoma patients, a diligent, exhaustive search for infiltrating cells in bone marrow is advised if thrombocytopenia or nucleated red blood cells are identified on a peripheral blood smear and bone marrow smears showed myeloid left shift with an increased number of erythroid cells.

Authors' Contributors

R.K. did study designing, conceptual analysis, data acquisition, and literature search. A.S. did literature search, and conceptual analysis and proof correction. S.R. did data analysis and designing. G.Y. did data analysis and proofreading. S.P.V. contributed to clinical studies and literature searches. U.S. Singh did study design and literature search.

Publication History

Article published online:
05 December 2022

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