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CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2023; 27(04): e586-e592
DOI: 10.1055/s-0042-1758219
Original Article

Glycyrrhizin and Mannitol Nasal Therapy: Cytological and Clinical Outcomes in Chronic Rhinitis

Giulio Pagliuca 
1   Otolaryngology University Unit, “S.M. Goretti Hospital”, Latina, Italy
,
Veronica Clemenzi 
2   Department of Sensorial Organs, ENT Section, “Sapienza” University of Rome, Rome, Italy
,
Salvatore Martellucci 
1   Otolaryngology University Unit, “S.M. Goretti Hospital”, Latina, Italy
,
Francesco Gazia 
3   Department of Adult and Development Age Human Pathology “Gaetano Barresi”, Otorhinolaryngology Unit, Messina, Italy
,
Sara Santarsiero 
4   Otorhinolaryngology Unit, Pediatric Hospital “Bambino Gesù”, Roma, Italy
,
Luigi Farina 
2   Department of Sensorial Organs, ENT Section, “Sapienza” University of Rome, Rome, Italy
,
Andrea Stolfa 
2   Department of Sensorial Organs, ENT Section, “Sapienza” University of Rome, Rome, Italy
,
Andrea Gallo 
2   Department of Sensorial Organs, ENT Section, “Sapienza” University of Rome, Rome, Italy
› Author Affiliations Funding The present study did not receive any funding from either private, public, or not-for-profit organizations.
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Abstract

Introduction Chronic rhinitis (CR) represents a widespread inflammation with a high incidence in the general population. Although it is generally considered a benign condition, CR has a relevant impact on quality of life and requires a specific treatment approach.

Objective The aim of the present study was to investigate the efficacy of glycyrrhizin and mannitol intranasal treatment on chronic rhinitis using cytological analysis and subjective evaluation of symptoms.

Methods A total of 55 patients suffering from chronic rhinitis were enrolled in the present study, 34 with allergic rhinitis (AR) and 21 with nonallergic rhinitis (NAR). The severity of four different nasal symptoms was determined by using a visual analogue scale (VAS). Specimens obtained by nasal scraping were collected for cytological analysis. Data were acquired before and after a 30-day treatment with glycyrrhizin and mannitol nasal spray. Statistical analyses were performed.

Results The VAS scores for all four nasal symptoms considered in the present study, as well as for neutrophil cells, reduced significantly after therapy in both allergic and nonallergic patients. The number of eosinophils was not significantly lower in nonallergic patients.

Conclusion A 30-day topical treatment with glycyrrhizin and mannitol may improve nasal symptoms and reduce inflammatory cells in the nasal mucosa in patients with chronic rhinitis without significant contraindications. Further studies could support our results and would better clarify all the aspects of this treatment.

Keywords

allergic rhinitis - cytology - glycyrrhizin - glycyrrhetinic acid - mannitol - therapy


Publication History

Received: 18 May 2022

Accepted: 19 July 2022

Article published online:
03 March 2023

© 2023. Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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