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CC BY-NC-ND 4.0 · J Pediatr Infect Dis 2022; 17(06): 269-274
DOI: 10.1055/s-0042-1757882
Original Article

Association between Interleukin-6 rs1800795 Polymorphism and Serum Interleukin-6 Levels and Full-Term Neonatal Sepsis

Xiao-Fen Zhao    #
1   Department of Neonatology, Kunming Children's Hospital, Yunnan, China
,
Mi-feng Yang   #
1   Department of Neonatology, Kunming Children's Hospital, Yunnan, China
,
Yu-qin Wu   #
1   Department of Neonatology, Kunming Children's Hospital, Yunnan, China
,
Peng-na Zhao
1   Department of Neonatology, Kunming Children's Hospital, Yunnan, China
,
Shuang-Yan Zhu
1   Department of Neonatology, Kunming Children's Hospital, Yunnan, China
,
Fei Xiong
1   Department of Neonatology, Kunming Children's Hospital, Yunnan, China
,
Mao Fan
1   Department of Neonatology, Kunming Children's Hospital, Yunnan, China
,
Yang-Fang Li
1   Department of Neonatology, Kunming Children's Hospital, Yunnan, China
› Author Affiliations Funding This work was supported by Kunming Municipal Health Commission (2020-06-03-001); National Nature Science Foundation of China (82060291).
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Erratum: Association between Interleukin-6 rs1800795 Polymorphism and Serum Interleukin-6 Levels and Full-Term Neonatal SepsisJ Pediatr Infect Dis 2022; 17(06): e1-e1
DOI: 10.1055/s-0043-1762601

Abstract

Objective Cytokines are involved in the pathogenesis of sepsis. Association between IL-6 rs1800795 G/C polymorphism and the risks of sepsis is controversial. The aim of this study was to investigate the association of IL-6 rs1800795 G/C gene polymorphism with full-term neonatal sepsis and to determine its effect on the serum IL6 levels in these infants by a prospective study.

Methods The study included 200 full-term neonates from January 2019 to December 2020: 100 with sepsis (sepsis group), 47 with culture proven sepsis, and 53 with clinical sepsis, and 100 without infection (control group). The concentrations of IL-6 in serum were determined using enzyme-linked immunosorbent assay (ELISA). The polymorphisms of IL-6 rs1800795 G/C were analyzed to compare the genotypic and allelic frequencies in the groups by using the first-generation sequencing (Sanger sequencing). The association was studied between IL-6 rs1800795 G/C polymorphisms and serum IL-6 levels, and neonatal sepsis. The relationships between IL-6 rs1800795G/C polymorphisms and sepsis and serum IL-6 levels were separately analyzed by logistic regression and analysis of variance.

Results There were no significant differences in genotypic frequencies and allelic frequencies of IL-6 rs1800795(G/C) in the groups (p >0.05). There were no relations between IL-6 rs1800795G/C polymorphisms and sepsis and serum IL-6 levels by statistical analysis (p >0.05).

Conclusion IL-6rs1800795G/C may not be genetic risk factors for full-term neonates; There was no association between serum IL-6 levels and IL-6 rs1800795G/C polymorphisms.

Keywords

interleukin-6 - polymorphism - sepsis - full-term neonates

# Co-first authors.




Publication History

Received: 14 May 2022

Accepted: 12 September 2022

Article published online:
07 November 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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