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CC BY-NC-ND 4.0 · Asian J Neurosurg 2024; 19(04): 634-640
DOI: 10.1055/s-0042-1757727
Original Article

Efficacy of Ventriculoperitoneal Shunt for Postoperative Central Nervous System Infection Complicated with Hydrocephalus

FuMei Chen   *
1   Emergency and Trauma Center, The International Medical Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
,
Na Wang   *
1   Emergency and Trauma Center, The International Medical Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
,
Li Wang   *
2   Intensive Care Unit, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China
,
ZhiYang He   *
1   Emergency and Trauma Center, The International Medical Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
,
KangLi Xu
1   Emergency and Trauma Center, The International Medical Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
,
TianXiang Zhan
3   Department of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
,
Qian Zhou
1   Emergency and Trauma Center, The International Medical Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
,
Hao Wang
3   Department of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
,
XiaoFeng Yang
1   Emergency and Trauma Center, The International Medical Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
› Author Affiliations Funding We acknowledge the support received from the National Natural Science Foundation of China (No. 81470052).
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Abstract

Objective Our aim was to assess the efficacy of ventriculoperitoneal shunt (VPS) for treating postoperative central nervous system infection (PCNSI) complicated with hydrocephalus and to identify factors associated with treatment failure.

Materials and Methods We conducted a retrospective analysis of PCNSI patients with hydrocephalus treated by VPS at the Department of Neurosurgery, the First Affiliated Hospital, College of Medicine, Zhejiang University, between December 2012 and January 2020. Functional recovery was evaluated during follow-up using the Glasgow Outcome Scale.

Results A total of 29 patients (21 males, 8 females) were enrolled in the study (mean age: 56.4 ± 12.0 years, range: 18.0–77.0 years). Seventeen patients were treated successfully by VPS (58.6%). Among the 11 patients with shunt complications (37.9%), 8 (27.6%) presented with fever, 3 (10.3%) with shunt infection, and 3 (10.3%) with shunt obstruction. Univariate analysis identified low Glasgow Coma Scale (GCS) score (3–8) at the time of VPS and post-treatment fever as predictive of shunt failure.

Conclusion VPS was effective for treating PCNSI complicated with hydrocephalus. However, patients with low GCS score at the time of VPS or fever post-treatment were at greater risk of shunt failure and poor outcome.

Keywords

ventriculoperitoneal shunt - postoperative central nervous system infection - hydrocephalus

Authors' Contributions

X.F.Y. and H.W. designed research, performed research, analyzed data. F.M.C., L.W., K.L.X., and T.X.Z. collected data, analyzed the data, and drafted the manuscript. N.W., Z.Y.H., Q.Z., and X.S.Z. collected and analyzed the data. All authors checked and agreed on the final manuscript.


Ethical Approval

This study was approved by the ethics committees of the First Affiliated Hospital, Zhejiang University School of Medicine. The requirement for obtaining informed consent from patients was waived because the datasets were anonymous. All methods were performed in accordance with the relevant guidelines and regulations.


* The four authors worked equally to the work and retain the first authorship.




Publication History

Article published online:
11 July 2024

© 2024. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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