CC BY-NC-ND 4.0 · Asian J Neurosurg 2022; 17(04): 631-634
DOI: 10.1055/s-0042-1757626
Case Report

Varied Clinical Presentation and Management of Calvarial Metastases

Sweety Gupta
1   Department of Radiation Oncology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
,
Gaurav Sharma
1   Department of Radiation Oncology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
,
Sanjay Sajeevan
1   Department of Radiation Oncology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
,
Sagar N. Raut
1   Department of Radiation Oncology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
,
Rachit Ahuja
2   Department of Radiation Oncology, Dr. Yashwant Singh Parmar Government Medical College, Nahan, Himachal Pradesh, India
,
Deepa Joseph
1   Department of Radiation Oncology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
,
Amit Gupta
3   Department of Surgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
,
Manoj Gupta
1   Department of Radiation Oncology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
› Author Affiliations
Funding None.

Abstract

Calvarium and skull base can be affected by a variety of benign, tumor-like, and malignant processes. Skull metastases (SMs) may be located in any layer of the skull and may be incidental or present with neurological symptoms during the diagnostic workup. In the present study, we discuss the occurrence of SMs from various index malignancies and their myriad clinical presentation. This data-based study includes patients of bone metastases between June 2018 and July 2020. Patients with skull bone metastases were recognized, and location of primary site, their clinical presentation, and management strategy were noted. Ten patients with skull bone metastases were identified during this period. Four patients had skull base location with clinical manifestation as syndromes. Six patients had primary from breast cancer, three from Ewing's sarcoma, and one from lung cancer. Management varied according to the primary site and symptoms of each patient. SM, though not rare, is often diagnosed incidentally but presents diagnostic and management challenges in the patient with cancer.



Publication History

Article published online:
18 October 2022

© 2022. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 
  • References

  • 1 Chin H, Kim J. Bone metastasis: concise overview. Fed Pract 2015; 32 (02) 24-30
  • 2 Shen J, Wang S, Zhao X. et al. Skull metastasis from follicular thyroid carcinoma: report of three cases and review of literature. Int J Clin Exp Pathol 2015; 8 (11) 15285-15293
  • 3 Takeda H, Ohe R, Fukui T. et al. Rapid progression of intracranial dural metastases in a patient with carcinoma of unknown primary site. Case Rep Oncol 2019; 12 (02) 666-670
  • 4 Stark AM, Eichmann T, Mehdorn HM. Skull metastases: clinical features, differential diagnosis, and review of the literature. Surg Neurol 2003; 60 (03) 219-225 , discussion 225–226
  • 5 Hong B, Hermann EJ, Klein R, Krauss JK, Nakamura M. Surgical resection of osteolytic calvarial lesions: clinicopathological features. Clin Neurol Neurosurg 2010; 112 (10) 865-869
  • 6 Mitsuya K, Nakasu Y, Horiguchi S. et al. Metastatic skull tumors: MRI features and a new conventional classification. J Neurooncol 2011; 104 (01) 239-245
  • 7 Ugga L, Cuocolo R, Cocozza S. et al. Spectrum of lytic lesions of the skull: a pictorial essay. Insights Imaging 2018; 9 (05) 845-856
  • 8 Kang YM, Lee HJ, Kim SJ. Metastatic breast cancer with osteolytic skull lesions suspected to be multiple myeloma. Korean J Clin Oncol 2017; 13 (02) 152-155
  • 9 Laigle-Donadey F, Taillibert S, Martin-Duverneuil N, Hildebrand J, Delattre JY. Skull-base metastases. J Neurooncol 2005; 75 (01) 63-69
  • 10 Kotecha R, Angelov L, Barnett GH. et al. Calvarial and skull base metastases: expanding the clinical utility of Gamma Knife surgery. J Neurosurg 2014; 121 (Suppl): 91-101
  • 11 Mitsuya K, Nakasu Y. Metastatic skull tumours: diagnosis and management. Eur Assoc Neuro Oncol Mag 2014; 4 (02) 71-74
  • 12 Altalhy A, Maghrabi Y, Almansouri Z, Baeesa SS. Solitary skull metastasis as the first presentation of a metachronous primary lung cancer in a survivor from pancreatic cancer. Case Rep Oncol Med 2017; 2017: 5674749
  • 13 Ben Nsir A, Boughamoura M, Maatouk M, Kilani M, Hattab N. Dural metastasis of Ewing's sarcoma. Surg Neurol Int 2013; 4: 96
  • 14 Rick JW, Shahin M, Chandra A. et al. Systemic therapy for brain metastases. Crit Rev Oncol Hematol 2019; 142: 44-50