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CC BY-NC-ND 4.0 · South Asian J Cancer 2025; 14(04): 694-697
DOI: 10.1055/s-0042-1757551
Original Article
Bone & Soft Tissue Section

Primary Intraosseous Synovial Sarcoma: Experience from a Tertiary Cancer Center

Authors

  • Vishnu Ramanujan

    1   Department of Surgical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India

  • Srikanth Soma

    1   Department of Surgical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India

  • Chandra Kumar Krishnan

    1   Department of Surgical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India

  • Kanuj Malik 

    1   Department of Surgical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India

  • Venkatraman Radhakrishnan 

    2   Department of Medical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India

  • Anand Raja 

    1   Department of Surgical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India
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Abstract

Introduction

Primary intraosseous synovial sarcoma (PISS) is a rare cancer of the bone, with few reported cases across literature. Data from our institute reveals seven indigenous cases. This study aims to evaluate these PISS diagnoses, and to further investigate any histopathological findings and prognostic factors associated with patient survival.

Materials and Methods

Data from patients diagnosed with PISS at the institute were obtained from January 1995 to December 2016, in the form of a retrospective study. Patient demographics, pathology locations, histological findings, surgical margins, and treatment modalities were audited as variables that can impact patient survival.

Results

This research identified seven cases which fulfilled the diagnostic criteria and were subsequently classified as PISS of the bone. There were five men and two women among the cases, with ages ranging from 16 to 46 years, with a mean of 29.6 years. The study found that the lower limb was the most affected site in PISS, followed by the pelvis. Limb salvage was performed in six patients and one patient underwent amputation. Of these patients, six received adjuvant chemotherapy and four received adjuvant radiation as per institution guidelines. The study found that the 5-year disease-free and overall survival rate was 80 and 61%, respectively.

Conclusion

PISS is a rare malignancy with limited cases in literature, and hence, there is no evidence for a standardized management protocol. The survival rates were similar between soft tissue and intraosseous synovial sarcoma among the case series.

Keywords

synovial sarcoma - bone - intraosseous - sarcoma - bone tumor - bone sarcoma

Ethical Approval

The study has been approved by the Institutional Ethics Committee of the Cancer Institute, Approval Number: IEC/2020/Nov 10.




Publication History

Article published online:
11 August 2023

© 2023. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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