CC BY-NC-ND 4.0 · Dental Journal of Advance Studies 2022; 10(03): 111-114
DOI: 10.1055/s-0042-1757547
Review Article

The Effect of Etiology on the Function of Hertwig's Epithelial Root Sheath in Regenerative Endodontic Procedures—A Review of Literature

Garima Garima
1   Department of Pedodontics and Preventive Dentistry, Yamuna Institute of Dental Sciences and Research, Yamuna Nagar, Haryana, India
Mayank Jain
2   Department of Oral Medicine and Radiology, Swami Devi Dyal Dental Hospital and Dental College, Panchkula, Haryana, India
Saloni Deol
3   Department of Prosthodontics, Yamuna Institute of Dental Sciences and Research, Yamuna Nagar, Haryana, India
Monia Sharma
4   Department of Periodontics, DAV Centenary Dental College, Yamuna Nagar, Haryana, India
Gaurav Ahuja
5   Orthodontics, Yamuna Institute of Dental Sciences and Research, Yamuna Nagar, Haryana, India
› Author Affiliations


The management of nonvital immature permanent teeth poses quite a challenge. The apexification procedure is in use for long-term now but the treated teeth are more prone to fracture questioning the long-term prognosis of this technique. The introduction of regenerative procedures for the treatment of these teeth is quite favorable; however, despite the increasing use of regenerative endodontic therapy procedures, inconsistent results are seen in the root development. Conservation of Hertwig's epithelial root sheath may have a prime role and selecting the cases with viable root sheath may impact on the consistent positive results treated with regenerative procedures. This article aims to look at the database to find the role of etiology and its implication on Hertwig's epithelial root sheath in the outcome of regenerative endodontics.

Publication History

Article published online:
12 October 2022

© 2022. Bhojia Dental College and Hospital affiliated to Himachal Pradesh University. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (

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