CC BY-NC-ND 4.0 · Dental Journal of Advance Studies 2022; 10(03): 145-149
DOI: 10.1055/s-0042-1757546
Original Article

Effect of Nonsurgical Periodontal Therapy on Adiponectin Levels in Type 2 Diabetics with Moderate to Severe Chronic Periodontitis-A Pilot Trial

Kanika Aggarwal
1   Department of Periodontology, Bhojia Dental College and Hospital, Baddi, Himachal Pradesh, India
Shipra Gupta
2   Unit of Periodontics, Oral Health Sciences Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Shaveta Sood
3   Department of Periodontology, Dr. Harvansh Singh Judge Institute of Dental Sciences & Hospital, Panjab University, Chandigarh, India
Nandini Bhaskar
3   Department of Periodontology, Dr. Harvansh Singh Judge Institute of Dental Sciences & Hospital, Panjab University, Chandigarh, India
4   Department of Biochemistry, Dr. Harvansh Singh Judge Institute of Dental Sciences & Hospital, Panjab University, Chandigarh, India
Vinay Kapur
5   Department of General Medicine, Dr. Harvansh Singh Judge Institute of Dental Sciences & Hospital, Panjab University, Chandigarh, India
› Author Affiliations


Background Adiponectin is a novel adipocyte-specific protein, which plays an important role in decreasing insulin resistance and inflammation, and hence can be considered in understanding the underlying mechanisms of both diabetes and periodontitis. As periodontitis and diabetes mellitus share common pathways of pathogenesis, this study was conducted to determine the effect of nonsurgical periodontal therapy on adiponectin levels in type 2 diabetics with moderate to severe chronic periodontitis.

Material and Methods Ten poorly controlled type 2 diabetics (hemoglobin A1c [HbA1c] ≥ 6.5%) with moderate to severe periodontitis (test group) and 10 age, sex, and body mass index matched systemically healthy patients with moderate to severe periodontitis (control group) were recruited. All the subjects underwent nonsurgical periodontal therapy. Gingival crevicular fluid (GCF) and serum were collected at the baseline and 3 months after periodontal treatment for assessment of adiponectin levels.

Results Adiponectin levels increased postperiodontal therapy in both the groups, both in GCF (p = 0.206, 0.12) and serum (p = 0.051, 0.06). HbA1c reduced in the test group posttreatment (p = 0.229).

Conclusion Nonsurgical periodontal therapy affects adiponectin levels locally as well as systemically thereby leading to improvement of glycemic control.

Authors' Contributions

A.K., G.S., S.S., and B.N. conceptualized and designed the study. A.K., G.S., S.S., B.N., and K.V. collected the data. A.K., G.S., S.S., B.N., and G.M. conducted the laboratory investigations. A.K., G.S., S.S., B.N., and G.M. analyzed and interpreted the results. A.K., G.S., S.S., and B.N. wrote the manuscript. G.S., S.S., B.N., A.K., and G.M. edited the manuscript and critically reviewed it.

All authors approved the final submitted version of the manuscript. A.K., G.S., S.S., and N.B. are the “guarantors” for the current study. Each author believes that the manuscript represents honest work.

This work belongs to : Department of Periodontics, Dr. Harvansh Singh Judge Institute of Dental Sciences and Hospital, Panjab University, Chandigarh, India

Publication History

Article published online:
12 October 2022

© 2022. Bhojia Dental College and Hospital affiliated to Himachal Pradesh University. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (

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