The Pathophysiological Role of Platelet-Derived Extracellular Vesicles

Meryem Mabrouk; Fadila Guessous; Abdallah Naya; Yahye Merhi; Younes Zaid

doi:10.1055/s-0042-1756705

Seminars in Thrombosis and Hemostasis, Table of Contents

CC BY 4.0 · Semin Thromb Hemost 2023; 49(03): 279-283
DOI: 10.1055/s-0042-1756705

Review Article

The Pathophysiological Role of Platelet-Derived Extracellular Vesicles

Authors

Meryem Mabrouk

¹Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco

²Department of Biology, Faculty of Sciences, Immunology and Biodiversity Laboratory, Hassan II University, Casablanca, Morocco
Fadila Guessous

³Research of Center, Faculty of Medicine, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco
Abdallah Naya

²Department of Biology, Faculty of Sciences, Immunology and Biodiversity Laboratory, Hassan II University, Casablanca, Morocco
Yahye Merhi

⁴Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Research Center, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada
Younes Zaid

¹Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco

²Department of Biology, Faculty of Sciences, Immunology and Biodiversity Laboratory, Hassan II University, Casablanca, Morocco

Abstract

Platelets are very abundant in the blood, where they play a role in hemostasis, inflammation, and immunity. When activated, platelets undergo a conformational change that allows the release of numerous effector molecules as well as the production of extracellular vesicles, which are circulating submicron vesicles (10 to 1,000 nm in diameter) released into the extracellular space. Extracellular vesicles are formed by the budding of platelet and they carry some of its contents, including nucleic acids, surface proteins, and organelles. While platelets cannot cross tissue barriers, platelet-derived extracellular vesicles can enter the lymph, bone marrow, and synovial fluid. This allows the transfer of diverse contents carried by these platelet-derived vesicles to cell recipients and organs inaccessible to platelets where they can perform many functions. This review highlights the importance of these platelet-derived extracellular vesicles under different physiological and pathophysiological conditions.

Keywords

extracellular vesicles - platelets - coagulation - platelet-derived extracellular vesicles

Full Text

References

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