Association of Chronic Periodontitis with Helicobacter pylori Infection in Stomach or Mouth: A Systematic Review and Meta-Analysis

Athanasios Tsimpiris; Ioannis Tsolianos; Andreas Grigoriadis; Ioannis Moschos; Dimitrios G. Goulis; Georgios Kouklakis

doi:10.1055/s-0042-1756690

European Journal of Dentistry, Table of Contents

CC BY 4.0 · Eur J Dent 2023; 17(02): 270-282
DOI: 10.1055/s-0042-1756690

Review Article

Association of Chronic Periodontitis with Helicobacter pylori Infection in Stomach or Mouth: A Systematic Review and Meta-Analysis

Authors

Athanasios Tsimpiris

¹Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece

²Dental Sector, 424 General Military Training Hospital, Thessaloniki, Greece
Ioannis Tsolianos

³Dental School, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece
Andreas Grigoriadis

²Dental Sector, 424 General Military Training Hospital, Thessaloniki, Greece

⁴Department of Preventive Dentistry, Periodontology and Implant Biology, Dental School, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece
Ioannis Moschos

⁵Department of Nursing, International Hellenic University, Thessaloniki, Greece
Dimitrios G. Goulis

⁶1st Department of Obstetrics and Gynecology, Unit of Reproductive Endocrinology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Georgios Kouklakis

⁷A΄ Department of Pathology, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece

Abstract

Helicobacter pylori (H. pylori) infection and periodontitis are both inflammatory conditions associated with systemic diseases. Researchers have attempted to investigate the correlation between them. This systematic review and meta-analyses were conducted to investigate the association of H. pylori infection in the stomach and/or in subgingival plaque and gingival crevicular fluid with chronic periodontitis. The protocol was created according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) statement. The study was designed according to the Cochrane criteria. A comprehensive literature search was performed in MEDLINE, Scopus, and CENTRAL, combined with hand-searching and assessment of gray literature. The meta-analysis of the included studies was made by the Review Manager (RevMan) 5.4 software. The effect measure of the outcome was odds ratios with 95% confidence intervals. Heterogeneity was assessed by chi-square and I². Four observational studies involving 818 subjects were included in this meta-analysis. The odds of oral H. pylori presence were higher in patients with chronic periodontitis, compared to healthy controls, with an odds ratio of 1.87 (95% confidence interval 0.85–4.10; p = 0.12). The odds of the presence of H. pylori in the stomach also were higher in patients with chronic periodontitis, with an odds ratio of 1.80 (95% confidence interval 0.82–3.95; p = 0.15). There is no evidence for an association between chronic periodontitis and the prevalence of H. pylori, detected either in subgingival plaque and gingival crevicular fluid or in the stomach.

Keywords

chronic periodontitis - Helicobacter pylori - subgingival plaque - stomach - meta-analysis

Full Text

References

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