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CC BY-NC-ND 4.0 · Rev Bras Ortop (Sao Paulo) 2023; 58(01): 072-078
DOI: 10.1055/s-0042-1756332
Artigo Original
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The Effects of Hydrolyzed Collagen and Collagen Peptide in the Treatment of Superficial Chondral Lesions: An Experimental Study

Article in several languages: português | English

Authors

  • Deivid Ramos dos Santos 

    1   Laboratório de Cirurgia Experimental, Universidade do Estado do Pará, Belém, PA, Brasil

  • Debora Pinheiro Xavier 

    1   Laboratório de Cirurgia Experimental, Universidade do Estado do Pará, Belém, PA, Brasil

  • Letícia Amanda Pinheiro de Ataíde 

    1   Laboratório de Cirurgia Experimental, Universidade do Estado do Pará, Belém, PA, Brasil

  • Lívia Guerreiro de Barros Bentes 

    1   Laboratório de Cirurgia Experimental, Universidade do Estado do Pará, Belém, PA, Brasil

  • Rafael Silva Lemos 

    1   Laboratório de Cirurgia Experimental, Universidade do Estado do Pará, Belém, PA, Brasil

  • Dante Bernardes Giubilei 

    2   Departamento de Ortopedia e Traumatologia do Hospital Porto Dias, Belém, PA, Brasil

  • Rui Sergio Monteiro de Barros 

    2   Departamento de Ortopedia e Traumatologia do Hospital Porto Dias, Belém, PA, Brasil
    3   Universidade do Estado do Pará, Belém, PA, Brasil
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Abstract

Objective To evaluate the effects of hydrolyzed collagen and collagen peptide in the treatment of superficial chondral lesions in rats.

Method This research employed 18 Rattus norvegicus. A single intraarticular infiltration of sodium iodoacetate (2 mg solution) through the patellar ligament induced joint damage in previously anesthetized animals. We divided the animals into three groups: a control group, a collagen peptide group, and a hydrolyzed collagen group. Treatment consisted of oral administration of collagen peptide or hydrolyzed collagen for 30 days. Afterwards, we euthanized the animals and studied the joint chondral changes. We evaluated the results according to the chondrocyte clusters count and a histological evaluation, as per Pritzker et al.

Results There was no statistical significance in injury stages between the control, hydrolyzed collagen, and collagen peptide groups (p = 0.11). Regarding scores, there was a statistical significance between the groups treated with hydrolyzed collagen and collagen peptide (p < 0.05), but not in comparison with the control group.

Conclusion The proposed treatments of the induced chondral lesion with the oral administration of hydrolyzed collagen or collagen peptides were effective, resulting in lesion stabilization or regression, and warranting further experimental research to understand and improve the primary outcome of this study.

Keywords

chondral lesion - collagen - knee - rats - treatment

Author's contributions

DRS and RSMB: study conception and design. DRS, DBG, and LAPA: performance of experimental procedures. LGBB and RSL: laboratorial analysis. DPX, DBG, and DRS: data analysis and histology. RSMB, DRS, and DPX: manuscript preparation, final review, and submission.


Financial Support

There was no support from public, commercial, or non-profit sources.


Multicentric study developed at the Experimental Surgery Laboratory from the Universidade do Estado do Pará (UEPA) and the Porto Dias Hospital, Belém, Pará, Brazil.




Publication History

Received: 13 May 2021

Accepted: 18 July 2022

Article published online:
20 October 2022

© 2022. Sociedade Brasileira de Ortopedia e Traumatologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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