CC BY-NC-ND 4.0 · Ann Natl Acad Med Sci 2022; 58(02): 055-059
DOI: 10.1055/s-0042-1756285

A Silent Pandemic of Antimicrobial Resistance: Challenges and Strategy for Preparedness in India

Yogendra Kumar Gupta
1   Former Dean and HOD Pharmacology, All India Institute of Medical Sciences, New Delhi, India
2   Global Antibiotics Research and Development Partnership, Switzerland
Subasree Srinivasan
2   Global Antibiotics Research and Development Partnership, Switzerland
› Author Affiliations

In the face of growing resistance against existing antibiotics and a dried-up pipeline of newer agents, the world is heading toward a silent pandemic. Globally, an estimated 4.95 million deaths occurred in 2019 due to drug-resistant infections including 1.27 million deaths attributable directly to bacterial antimicrobial resistance (AMR).[1] As per projected estimates, by 2050, AMR would cause approximately 10 million deaths worldwide and 2 million deaths in India.[1] [2] Recently (2019), in World Health Organization's (WHO) list of 10 threats to global health, AMR stands on fifth place.[3] In the preantibiotic era, infectious diseases were the primary cause of mortality worldwide. Today, if AMR left unchecked, treatable infections will lead to huge increases in fatality from bacterial infections worldwide. The resistance to first line of empirical therapy (β-lactam antibiotics and fluroquinolones) against six priority pathogens (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus pneumoniae, Acinetobacter baumannii, and Pseudomonas. aeruginosa) accounted for more than 70% deaths globally.[1] This continued escalation puts at risk the very practice of modern medicine, unless drastic measures are taken today to counter this threat.

Publication History

Article published online:
04 October 2022

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