Unraveling the Complexity of Liver Disease One Cell at a Time

Jawairia Atif; Cornelia Thoeni; Gary D. Bader; Ian D. McGilvray; Sonya A. MacParland

doi:10.1055/s-0042-1755272

Seminars in Liver Disease, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Semin Liver Dis 2022; 42(03): 250-270
DOI: 10.1055/s-0042-1755272

Review Article

Unraveling the Complexity of Liver Disease One Cell at a Time

Jawairia Atif

¹Ajmera Transplant Centre, Schwartz Reisman Liver Research Centre, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada

²Department of Immunology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada

,

Cornelia Thoeni

³Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

,

Gary D. Bader‡^*

⁴Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

⁵The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada

,

Ian D. McGilvray‡^*

¹Ajmera Transplant Centre, Schwartz Reisman Liver Research Centre, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada

,

Sonya A. MacParland‡^*

¹Ajmera Transplant Centre, Schwartz Reisman Liver Research Centre, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada

²Department of Immunology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada

³Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

› Institutsangaben

Abstract

The human liver is a complex organ made up of multiple specialized cell types that carry out key physiological functions. An incomplete understanding of liver biology limits our ability to develop therapeutics to prevent chronic liver diseases, liver cancers, and death as a result of organ failure. Recently, single-cell modalities have expanded our understanding of the cellular phenotypic heterogeneity and intercellular cross-talk in liver health and disease. This review summarizes these findings and looks forward to highlighting new avenues for the application of single-cell genomics to unravel unknown pathogenic pathways and disease mechanisms for the development of new therapeutics targeting liver pathology. As these technologies mature, their integration into clinical data analysis will aid in patient stratification and in developing treatment plans for patients suffering from liver disease.

Keywords

single-cell transcriptomics - liver cancer - hepatitis

Volltext

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